About the Authors

Nicole Droz

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, United States of America

Patrick Hanaway

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Center for Functional Medicine, Cleveland Clinic, Cleveland, OH, United States of America

Mark Hyman

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliation Center for Functional Medicine, Cleveland Clinic, Cleveland, OH, United States of America

Yuxuan Jin

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States of America

Michelle Beidelschies

Roles Writing – original draft, Writing – review & editing

Affiliation Center for Functional Medicine, Cleveland Clinic, Cleveland, OH, United States of America

M. Elaine Husni

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

HusniE@ccf.org

Affiliation Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, United States of America

Competing Interests

Nicole Droz, MD- none Yuxuan Jin- none Mark Hyman, MD- * Ownership of stocks or shares: Mutual funds and investments that may include medically or food related companies managed by investment broker, multiple private companies including Thrive Market, Hu Kitchen, Walden Meats, WTR MLN WTR, Parsley Health, Bulletproof, Good Money * Paid employment or consultancy: Cleveland Clinic and owner of The UltraWellness Center, Hyman Digital, Hyman Enterprises (published 16 books on health and nutrition), Vitamin Portfolio, Farmacy, The Doctor’s Farmacy podcast * Board membership: Institute for Functional Medicine, Environmental Working Group, Center for Mind Body Medicine Michelle Beidelschies, PhD: reported receiving personal fees from Cleveland HeartLab, Inc. outside the submitted work. In addition, Dr. Beidelschies had a patent (No. 20110269150) issued for compositions and methods for predicting cardiovascular events. M. Elaine Husni, MD MPH: Dr. Husni is a consultant (with honoraria) from AbbVie, Janssen, Sanofi Genzyme/Regeneron, UCB, Novartis, and Lilly (less than $10,000 each) and is a coinventor on a psoriatic arthritis questionnaire PASE (Psoriatic Arthritis Screening Evaluation) which is copyrighted, for which she receives royalties. Patrick Hanaway, MD: Dr Hanaway reported serving as paid educational consultant and teaching for the Institute for Functional Medicine. This does not alter our adherence to PLOS ONE policies on sharing data and materials.