About the Authors

Toshihito Isono

Roles Investigation, Methodology, Writing – original draft

Affiliation Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Hisanori Domon

Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliations Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Research Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Kosuke Nagai

Roles Investigation, Methodology, Supervision

Affiliation Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Tomoki Maekawa

Roles Investigation, Project administration, Supervision

Affiliations Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Research Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Hikaru Tamura

Roles Investigation

Affiliations Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Research Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Takumi Hiyoshi

Roles Investigation, Methodology

Affiliations Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Katsunori Yanagihara

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Eiji Kunitomo

Roles Methodology, Resources, Supervision, Writing – review & editing

Affiliation Central Research and Development Laboratory, Kobayashi Pharmaceutical Co., Ltd., Osaka, Japan

Shoji Takenaka

Roles Investigation, Project administration, Supervision

Affiliation Division of Cariology, Operative Dentistry and Endodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

Yuichiro Noiri

Roles Methodology, Supervision, Writing – review & editing

Affiliation Division of Cariology, Operative Dentistry and Endodontics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

Yutaka Terao

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

terao@dent.niigata-u.ac.jp

Affiliations Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Research Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: Dr. Eiji Kunitomo is an employee of Kobayashi Pharmaceutical, Co., Ltd. The funder provided support in the form of salaries for author EK, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.