Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro

Neil R. Lloyd; Deborah S. Wuttke

doi:10.1371/journal.pone.0237956

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Open Access

Peer-reviewed

Research Article

Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro

Neil R. Lloyd,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Current address: KBI Biopharma, Louisville, CO, United States of America

Affiliation Department of Biochemistry, UCB 596, University of Colorado Boulder, Boulder, Colorado, United States of America
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Deborah S. Wuttke

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Deborah.wuttke@colorado.edu

Affiliation Department of Biochemistry, UCB 596, University of Colorado Boulder, Boulder, Colorado, United States of America

https://orcid.org/0000-0002-8158-8795

⨯

Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro

Neil R. Lloyd,
Deborah S. Wuttke

Published: February 19, 2021
https://doi.org/10.1371/journal.pone.0237956

About the Authors

Neil R. Lloyd

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Current address: KBI Biopharma, Louisville, CO, United States of America

Affiliation Department of Biochemistry, UCB 596, University of Colorado Boulder, Boulder, Colorado, United States of America

Deborah S. Wuttke

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: Deborah.wuttke@colorado.edu

Affiliation Department of Biochemistry, UCB 596, University of Colorado Boulder, Boulder, Colorado, United States of America

https://orcid.org/0000-0002-8158-8795

Competing Interests

The authors have declared that no competing interests exist.

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Isomerases
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RNA structure
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Polymerase chain reaction
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RNA sequencing
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Sequence motif analysis
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Gene regulation
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Transcriptional control
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RNA-binding proteins
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