About the Authors

Ben Niu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

ben.niu1@astrazeneca.com

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Michael Martinelli II

Roles Investigation, Methodology

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Yang Jiao

Roles Investigation, Methodology

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Chunlei Wang

Roles Investigation, Methodology, Writing – review & editing

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Mingyan Cao

Roles Investigation

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Jihong Wang

Roles Conceptualization, Writing – review & editing

Current address: Viela Bio, Gaithersburg, MD, United States of America

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Eric Meinke

Roles Conceptualization, Investigation

Current address: AveXis, Longmont, CO, United States of America

Affiliation Analytical Sciences, BioPharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD, United States of America

Competing Interests

For this research, scientists B.N., M.M., Y.J., C.W., M.C., J.W., E.M. were employed and funded by AstraZeneca. The funder provided support in the form of salaries for authors B.N., M.M., Y.J., C.W., M.C., J.W., E.M. There are no relevant patents, products in development, or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.