About the Authors

Shiro Imagama

Contributed equally to this work with: Shiro Imagama, Ryoko Ogino

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

imagama@med.nagoya-u.ac.jp (SI); ueno.shinya.br@daiichisankyo.co.jp (SU)

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

Ryoko Ogino

Contributed equally to this work with: Shiro Imagama, Ryoko Ogino

Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Shinya Ueno

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

imagama@med.nagoya-u.ac.jp (SI); ueno.shinya.br@daiichisankyo.co.jp (SU)

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Norihito Murayama

Roles Conceptualization, Data curation, Investigation, Methodology, Visualization

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Naohiro Takemoto

Roles Resources

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Yoshiari Shimmyo

Roles Investigation

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Taisuke Kadoshima

Roles Investigation

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Shigeki Tamura

Roles Investigation

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Mariko Kuroda

Roles Investigation

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Yukihiro Matsuyama

Roles Methodology, Project administration

Affiliation Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan

Kenji Kadomatsu

Roles Methodology, Project administration

Affiliation Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan

Yasuhiro Morita

Roles Investigation, Writing – review & editing

Affiliation Faculty of Pharmacy, Laboratory of Physiology and Morphology, Yasuda Women’s University, Hiroshima, Japan

Teruyoshi Inoue

Roles Supervision

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan

Naoki Ishiguro

Roles Supervision

Affiliation Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: S.I., K.K., Y.Ma. and Y.Mo. received research funding from Asubio Pharma Co. Ltd. R.O., S.U., N.M., N.T., Y.S., T.K., S.T.,M.K. and T.I. are employed by Asubio Pharma Co., Ltd. N.M. and N.T. are inventors on a patent granted (“Nitrogenated aromatic 6-membered ring derivative, and pharmaceutical agent comprising the same” Publication of US9139559B2). This does not alter our adherence to PLOS ONE policies on sharing data and materials