About the Authors

Dalia L. Rotstein

Roles Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

dalia.rotstein@unityhealth.to

Affiliations Department of Medicine, University of Toronto, Toronto, Ontario, Canada, St. Michael’s Hospital, Toronto, Ontario, Canada

Ruth Ann Marrie

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation Departments of Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

Karen Tu

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliations North York General Hospital, Toronto, Ontario, Canada, Departments of Family and Community Medicine and Institute for Health Policy and Management, University of Toronto, Toronto, Ontario, Canada, Toronto Western Hospital University Health Network, Toronto, Ontario, Canada

Susan E. Schultz

Roles Formal analysis, Writing – review & editing

Affiliation ICES, Toronto, Ontario, Canada

Kinwah Fung

Roles Formal analysis, Writing – review & editing

Affiliation ICES, Toronto, Ontario, Canada

Colleen J. Maxwell

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations ICES, Toronto, Ontario, Canada, Schools of Pharmacy and Public Health and Health Systems, University of Waterloo, Waterloo, ON, Canada

Competing Interests

Dalia Rotstein has received research support from the Consortium of Multiple Sclerosis Centers (CMSC), the Multiple Sclerosis Society of Canada, and Roche Canada. She has served as a speaker or consultant for Alexion, Biogen, EMD Serono, Novartis, Roche and Sanofi Aventis. Ruth Ann Marrie receives research funding from: CIHR, Research Manitoba, Multiple Sclerosis Society of Canada, Multiple Sclerosis Scientific Foundation, Crohn’s and Colitis Canada, National Multiple Sclerosis Society, CMSC and United States Department of Defence. She is supported by the Waugh Family Chair in Multiple Sclerosis. Karen Tu has received research funding from the Department of Defense United States of America, MaRS Innovation Fund, Canadian Institutes of Health Research Cover Letter (CIHR), Rathlyn Foundation, Canadian Dermatology Foundation, Canadian Rheumatology Association (CRA), Canadian Initiative for Outcomes in Rheumatology Care (CIORA), Toronto Rehab Institute Chair Fund, University of Toronto Practice-Based Research Network (UTOPIAN), PSI Foundation, Cancer Care Ontario (CCO) Clinical Programs & Quality Initiatives, Arthritis Society, McLaughlin Centre Accelerator Grant, MS Society of Canada and Consortium of MS Centers, Ontario SPOR Support Unit, Ontario Institute for Cancer Research (OICR) Health Services Research Program, Vascular Network and Heart and Stroke Foundation of Ontario. She also receives a research scholar award from the Department of Family and Community Medicine at the University of Toronto. Susan Schultz has nothing to disclose. Kinwah Fung has nothing to disclose. Colleen Maxwell has received research funding from the Canadian Institutes of Health Research, P.S.I. Foundation, MS Society of Canada, Consortium of MS Centers, MS Scientific Research Foundation, Ontario Ministry of Health and Long-Term Care-Health System Research Fund, Canadian Frailty Network, Partners for Canadian Consortium on Neurodegeneration in Aging, Network for Aging Research-University of Waterloo. She is supported by a University Research Chair at the University of Waterloo. This does not alter our adherence to PLOS ONE policies on sharing data and materials.