About the Authors

Elyssa B. Margolis

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

elyssa.margolis@ucsf.edu

Affiliation Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States of America

Tanya L. Wallace

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation BlackThorn Therapeutics, San Francisco, CA, United States of America

Lori Jean Van Orden

Roles Conceptualization, Writing – review & editing

Affiliation BlackThorn Therapeutics, San Francisco, CA, United States of America

William J. Martin

Roles Conceptualization, Writing – review & editing

Affiliation BlackThorn Therapeutics, San Francisco, CA, United States of America

Competing Interests

Competing interest: TLW, LJVO and WJM are employees of BlackThorn Therapeutics and have ownership interest (stock, stock options, royalty, receipt of intellectual property rights/patent holder, excluding diversified mutual funds) in BlackThorn Therapeutics TLW, LJVO, WJM have no other competing interests to declare. TLW, LJVO, WJM affiliation with BlackThorn Therapeutics and patent (WO2018170492; Kappa Opioid Receptor Antagonists and Products and Methods Related Thereto) does not alter our adherence to PLOS ONE policies on sharing data and materials.