About the Authors

Ricky Lieu

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliation Biotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, United States of America

Stephen Antonysamy

Roles Investigation

Affiliation Discovery Chemistry Research and Technologies, Eli Lilly and Company Corporate Center, Indianapolis, IN, United States of America

Zhanna Druzina

Roles Investigation, Writing – original draft

Current address: Protein Engineering, Aro Biotherapeutics Company, Philadelphia, PA, United States of America

Affiliation Discovery Chemistry Research and Technologies, Eli Lilly and Company Corporate Center, Indianapolis, IN, United States of America

Carolyn Ho

Roles Investigation, Writing – original draft

Affiliation Biotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, United States of America

N. Rebecca Kang

Roles Investigation

Current address: Department of Biomedical Engineering, Boston University, Boston, MA, United States of America

Affiliation Biotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, United States of America

Anna Pustilnik

Roles Investigation, Writing – original draft

Affiliation Discovery Chemistry Research and Technologies, Eli Lilly and Company Corporate Center, Indianapolis, IN, United States of America

Jing Wang

Roles Data curation, Investigation

Affiliation Discovery Chemistry Research and Technologies, Eli Lilly and Company Corporate Center, Indianapolis, IN, United States of America

Shane Atwell

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

satwell@lilly.com

Affiliation Biotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, United States of America

Competing Interests

RL, SA, ZD, CH, NRK, AP, JW and SA are, or were at the time of the work described here, employees of Eli Lilly & Co. Eli Lilly & Co. provided support in the form of salaries for the authors and research funding. Eli Lilly & Co. also approved the publication of this work. Eli Lilly & Co. has filed a patent application related to the work described here. The employment of the authors by Eli Lilly & Co does not alter our adherence to PLOS ONE policies on data sharing and materials.