About the Authors

Gábor Kovács

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Syreon Research Institute, Budapest, Hungary

Giovanna Devercelli

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Shire, a Takeda company, Lexington, Massachusetts, United States of America

Tamás Zelei

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Syreon Research Institute, Budapest, Hungary

Ishan Hirji

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Shire, a Takeda company, Lexington, Massachusetts, United States of America

Zoltán Vokó

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations Syreon Research Institute, Budapest, Hungary, Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary

Paul A. Keown

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

paul.keown@ubc.ca

Affiliations Syreon Corporation, Vancouver, British Columbia, Canada, University of British Columbia, Vancouver, British Columbia, Canada

Competing Interests

This research was funded by the sponsor, Shire Human Genetic Therapies, Inc., a Takeda company. Shire Human Genetic Therapies, Inc., a Takeda company, provided funding to Excel Medical Affairs for support in writing and editing this manuscript. The interpretation of the data was made by the authors independently. GK is a contracted partner of Syreon Research Institute. GD and IH are employees of Shire, a Takeda company. TZ is a fulltime employee of Syreon Research Institute. ZV is a shareholder and part-time employee of Syreon Research Institute. PAK is the principal shareholder in and principal of Syreon Corporation, which conducts health sciences research and clinical trials for numerous pharmaceutical companies, and has received travel support related to these activities; PAK has received a grant from Genome Canada and matching funds from corporations, and is an originator of three patents related to transplantation research, but not directly to this systematic review, that are held by the University of British Columbia. GK, TZ, ZV, and PAK have performed contracted research for Shire, a Takeda company. This does not alter our adherence to PLOS ONE policies on sharing data and materials.