About the Authors

E. Driehuis

Contributed equally to this work with: E. Driehuis, N. Oosterom

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

N. Oosterom

Contributed equally to this work with: E. Driehuis, N. Oosterom

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

S. G. Heil

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

I. B. Muller

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

M. Lin

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

S. Kolders

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands

G. Jansen

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Amsterdam Rheumatology and Immunology Center, Department of Rheumatology, Amsterdam UMC, Amsterdam, The Netherlands

R. de Jonge

Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliation Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands

R. Pieters

Roles Supervision, Writing – review & editing

Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

H. Clevers

Roles Resources, Supervision, Writing – review & editing

Affiliations Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

M. M. van den Heuvel-Eibrink

Roles Conceptualization, Resources, Supervision, Writing – review & editing

m.m.vandenheuvel-eibrink@prinsesmaximacentrum.nl

Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

Competing Interests

H.C. is an inventor on several patents related to organoid technology. E.D. is inventor on a patent related to the culturing of organoids derived of normal and tumor tissue of the head and neck area. The relevant patent numbers are: WO2009/022907, WO2010/090513, WO2012/168930. This does not alter our adherence to PLOS ONE policies on sharing data and materials.