About the Authors

Masato Yugami

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

masato.yugami@takeda.com (MYu); myano@med.niigata-u.ac.jp (MYa)

Affiliation Takeda Pharmaceutical Company, Ltd, Osaka, Japan

Hideyuki Okano

Roles Funding acquisition, Project administration, Validation, Writing – review & editing

Affiliation Department of Physiology, School of Medicine, Keio University, Minato, Japan

Atsushi Nakanishi

Roles Project administration, Validation, Writing – review & editing

Affiliation Takeda Pharmaceutical Company, Ltd, Osaka, Japan

Masato Yano

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

masato.yugami@takeda.com (MYu); myano@med.niigata-u.ac.jp (MYa)

Affiliations Department of Physiology, School of Medicine, Keio University, Minato, Japan, Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

Competing Interests

H.O. is a paid member of the Scientific Advisory Board of San Bio Co., Ltd. And K Pharma, Inc. M. Yano is a scientific advisor of K Pharma, Inc. M. Yugami and A.N. received funding in the form of salary from Takeda Pharmaceutical Company, Ltd. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.