About the Authors

Sarah Piel

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

sarah.piel@med.lu.se

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden, Department of Anesthesiology and Critical Care Medicine, Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, United States of America

Imen Chamkha

Roles Data curation, Writing – review & editing

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

Adam Kozak Dehlin

Roles Data curation, Writing – review & editing

Affiliation Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden

Johannes K. Ehinger

Roles Conceptualization, Writing – review & editing

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

Fredrik Sjövall

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, Department of Clinical Sciences Lund, Skane University Hospital, Intensive Care and Perioperative Medicine, Lund University, Malmö, Sweden

Eskil Elmér

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden, Department of Clinical Sciences Lund, Skane University Hospital, Clinical Neurophysiology, Lund University, Lund, Sweden

Magnus J. Hansson

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliations Department of Clinical Sciences Lund, Mitochondrial Medicine, Lund University, Lund, Sweden, NeuroVive Pharmaceutical AB, Medicon Village, Lund, Sweden

Competing Interests

S.P., J.K.E., I.C., F.S., E.E., and M.J.H have, or have had, salary from and/or equity interest in NeuroVive Pharmaceutical AB, a company active in the field of mitochondrial medicine. S.P., J.K.E., E.E., and M.J.H have filed patent applications for the use of succinate prodrugs for treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation (WO/2015/155238) and protected carboxylic acid based metabolites for treatment of mitochondrial disorders (WO/2017/060400, WO/2017/060418, WO/2017/060422). This does not alter our adherence to PLOS ONE policies on sharing data and materials.