About the Authors

Shelli Schomaker

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Drug Safety R&D, Pfizer, Inc, Groton, CT, United States of America

David Potter

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Drug Safety R&D, Pfizer, Inc, Groton, CT, United States of America

Roscoe Warner

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation University of Michigan, Ann Arbor, MI, United States of America

Jane Larkindale

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Critical Path Institute, Tucson, AZ, United States of America

Nicholas King

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Critical Path Institute, Tucson, AZ, United States of America

Amy C. Porter

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Critical Path Institute, Tucson, AZ, United States of America

Jane Owens

Roles Data curation, Formal analysis

Affiliation Rare Disease Research Unit, Pfizer, Inc, Cambridge, MA, United States of America

Lindsay Tomlinson

Roles Data curation, Formal analysis

Affiliation Drug Safety R&D, Pfizer, Inc, Groton, CT, United States of America

John-Michael Sauer

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Critical Path Institute, Tucson, AZ, United States of America

Kent Johnson

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation University of Michigan, Ann Arbor, MI, United States of America

Jiri Aubrecht

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Jiri.Aubrecht@takeda.com

Current address: Takeda Pharmaceuticals, Cambridge, MA, United States of America

Affiliation Drug Safety R&D, Pfizer, Inc, Groton, CT, United States of America

Competing Interests

The project was funded by Pfizer Inc. in forms of research grants to K.J.J and R.W. (University of Michigan). Critical Path Institute provided salary support to J.L., A.C.P., and J-M.S. Pfizer Inc. provided support in the form of salaries for authors [S.J.S., J.O., T.L., and J.A.]. Critical Path Institute and Pfizer Inc reviewed the final manuscript, but the funding organizations did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. None of the authors serve on the editorial board of PLOS ONE. None of the authors have acted as an expert witness in relevant legal proceedings. None of the authors have sat or currently sit on a committee for an organization that may benefit from publication of the paper. This does not alter our adherence to PLOS ONE policies on sharing data and materials.