About the Authors

Glen S. Hazlewood

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

ggkaplan@ucalgary.ca (GK); gshazlew@ucalgary.ca (GH)

Affiliation Department of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Gyanendra Pokharel

Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Mathematics and Statistics, University of Calgary, Calgary, Alberta, Canada

Robert Deardon

Roles Formal analysis, Methodology, Supervision, Visualization, Writing – review & editing

Affiliations Department of Mathematics and Statistics, University of Calgary, Calgary, Alberta, Canada, Department of Production of Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

Deborah A. Marshall

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Claire Bombardier

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations Department of Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

George Tomlinson

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation Department of Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada

Christopher Ma

Roles Methodology, Writing – review & editing

Affiliation Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Cynthia H. Seow

Roles Methodology, Writing – review & editing

Affiliation Department of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Remo Panaccione

Roles Methodology, Writing – review & editing

Affiliation Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Gilaad G. Kaplan

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

ggkaplan@ucalgary.ca (GK); gshazlew@ucalgary.ca (GH)

Affiliations Department of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada, Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Competing Interests

Dr. Hazlewood, Dr. Pokharel, Dr. Deardon, Dr. Tomlinson and Dr. Ma have nothing to declare. Dr. Marshall has received honoraria and travel expenses from Abbvie, Pfizer, Novartis, and Johnson and Johnson for presentations and participation on advisory boards and has been a consultant for Merck. Dr. Bombardier holds a Pfizer Chair and a Canada Research Chair in Knowledge Transfer for Musculoskeletal Care and has received grant support from Janssen, Pfizer, Amgen, Abbott/Abbvie Canada, BMS, Celgene, Eli Lilly, Fresenius Kabi, Hoffman La Roche, Sanofi, UCB, and Calea, has acted as a consultant for AstraZeneca, Abbott/Abbvie Canada and BMS, and has participated in advisory board meetings for Janssen, Pfizer, Amgen, and AstraZeneca. Dr. Panaccione has served as a speaker, a consultant and an advisory board member for Abbott Laboratories, Merck, Schering-Plough, Shire, Centocor, Elan Pharmaceuticals, and Procter and Gamble. He has served as a consultant and speaker for Astra Zeneca. He has served as a consultant and an advisory board member for Ferring and UCB. He has served as a consultant for Glaxo-Smith Kline and Bristol Meyers Squibb. He has served as a speaker for Byk Solvay, Axcan, Jansen, and Prometheus. He has received research funding from Merck, Schering-Plough, Abbott Laboratories, Elan Pharmaceuticals, Procter and Gamble, Bristol Meyers Squibb, and Millennium Pharmaceuticals. He has received educational support from Merck, Schering-Plough, Ferring, Axcan, and Jansen. Dr. Cynthia H. Seow has served as a speaker and participated in advisory board meetings for Janssen, Abbvie, Takeda, Shire and Ferring. Dr. Kaplan has received honoraria for speaking or consultancy from Abbvie, Janssen, Pfizer, and Takeda. He has received research support from Janssen, Abbvie, GlaxoSmith Kline, Merck, and Shire. He shares a patent: TREATMENT OF INFLAMMATORY DISORDERS, AUTOIMMUNE DISEASE, AND PBC. UTI Limited Partnership, assignee. Patent 62/555,397. 7 Sept. 2017. This patent relates to the potential therapeutic effect of mirtazapine on immune mediated disease such as inflammatory bowel disease. However, mirtazapine is not directly studied in the current publication. This does not alter our adherence to PLOS ONE policies on sharing data.