About the Authors

Takumi Toya

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America, Department of Cardiology, National Defense Medical College, Tokorozawa, Saitama, Japan

Michel T. Corban

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America

Eric Marrietta

Roles Data curation, Investigation

Affiliation Department of Gastroenterology, Mayo Clinic, Rochester, MN, United States of America

Irina E. Horwath

Roles Investigation

Affiliation Department of Gastroenterology, Mayo Clinic, Rochester, MN, United States of America

Lilach O. Lerman

Roles Writing – review & editing

Affiliation Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States of America

Joseph A. Murray

Roles Writing – review & editing

Affiliation Department of Gastroenterology, Mayo Clinic, Rochester, MN, United States of America

Amir Lerman

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Lerman.Amir@mayo.edu

Affiliation Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America

Competing Interests

This study was sponsored by unrestricted grants from Sonomaceuticals, LLC, dba Whole-Vine Products (Santa Rosa, CA) and Mayo Clinic (Rochester, MN) to AL. This does not alter our adherence to PLOS ONE policies on sharing data and materials.