Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

Yuan-Jian Yang; Tao Luo; Ying Zhao; Shu-Zhen Jiang; Jian-Wen Xiong; Jin-Qiong Zhan; Bin Yu; Kun Yan; Bo Wei

doi:10.1371/journal.pone.0226688

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Peer-reviewed

Research Article

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

Yuan-Jian Yang ,

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation, Writing – original draft

Affiliations Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Tao Luo ,

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation

Affiliation Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Ying Zhao ,

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation

Affiliation Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
⨯
Shu-Zhen Jiang,

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Jian-Wen Xiong,

Roles Investigation

Affiliation Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Jin-Qiong Zhan,

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Bin Yu,

Roles Investigation

Affiliations Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Kun Yan,

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China
⨯
Bo Wei

Roles Project administration, Writing – review & editing

* E-mail: jxmh_wb@163.com

Affiliations Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

http://orcid.org/0000-0002-9135-7624

⨯

Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

Yuan-Jian Yang,
Tao Luo,
Ying Zhao,
Shu-Zhen Jiang,
Jian-Wen Xiong,
Jin-Qiong Zhan,
Bin Yu,
Kun Yan,
Bo Wei

Published: March 19, 2020
https://doi.org/10.1371/journal.pone.0226688

About the Authors

Yuan-Jian Yang

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation, Writing – original draft

Affiliations Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Tao Luo

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation

Affiliation Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Ying Zhao

Contributed equally to this work with: Yuan-Jian Yang, Tao Luo, Ying Zhao

Roles Investigation

Affiliation Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China

Shu-Zhen Jiang

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Jian-Wen Xiong

Roles Investigation

Affiliation Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Jin-Qiong Zhan

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Bin Yu

Roles Investigation

Kun Yan

Roles Investigation

Affiliation Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, P.R. China

Bo Wei

Roles Project administration, Writing – review & editing

* E-mail: jxmh_wb@163.com

http://orcid.org/0000-0002-9135-7624

Competing Interests

The authors have declared that no competing interests exist.

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Schizophrenia
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Working memory
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Cognitive impairment
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Educational attainment
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Memory
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Antipsychotics
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Attention
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Hippocampus
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