About the Authors

John C. Zwaagstra

Roles Conceptualization, Data curation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

john.zwaagstra@nrc-cnrc.gc.ca (JZ); maria.jaramillo@nrc-cnrc.gc.ca (MJ)

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Traian Sulea

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Jason Baardsnes

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Stevo Radinovic

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Yuneivy Cepero-Donates

Roles Data curation, Formal analysis, Methodology

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Alma Robert

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Maureen D. O’Connor-McCourt

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Forbius, Montreal, Quebec, Canada

Ilia A. Tikhomirov

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Forbius, Montreal, Quebec, Canada

Maria Luz. Jaramillo

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

john.zwaagstra@nrc-cnrc.gc.ca (JZ); maria.jaramillo@nrc-cnrc.gc.ca (MJ)

Affiliation Human Health Therapeutics Research Centre, National Research Council Canada, Montreal, Quebec, Canada

Competing Interests

Forbius provided support for this study in the form of salaries for authors Maureen O’Connor-McCourt and Ilia Tikhomirov. There are no products in development or marketed products associated with this research to declare. Some mutants shown in Table 1 are disclosed in US patent USP10,208,129, which is assigned to the National Research Council Canada. This does not alter our adherence to PLOS ONE policies on sharing data and materials.