http://orcid.org/0000-0002-2810-0455
About the Authors
- Alessandro Lazdins
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Anand Prakash Maurya
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Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing
Current address: Indian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, India
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Claire E. Miller
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Roles Investigation, Methodology, Writing – review & editing
Current address: The Biohub, Birmingham Research Park Ltd, Edgbaston, Birmingham, United Kingdom
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Muhammad Kamruzzaman
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Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation University of Sydney, Centre for Infectious Disease & Microbiology, Westmead Institute of Medical Research, Westmead, New South Wales, Australia
- Shuting Liu
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Roles Investigation, Methodology, Writing – review & editing
Current address: Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois, United States of America
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Elton R. Stephens
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Roles Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Georgina S. Lloyd
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Roles Methodology, Project administration, Resources, Supervision, Writing – review & editing
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Mona Haratianfar
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Roles Investigation, Methodology, Writing – review & editing
Current address: Center for Regenerative Medicine, Boston University, Boston, Massachusetts, United States of America
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Melissa Chamberlain
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Roles Investigation, Methodology, Writing – review & editing
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Anthony S. Haines
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Roles Conceptualization, Methodology, Supervision, Writing – review & editing
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Jan-Ulrich Kreft
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Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Mark. A. Webber
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Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Current address: Quadram Institute, Norwich, Research Park, Norwich, Norfolk, England, United Kingdom
Affiliation Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
- Jonathan Iredell
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Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing
Affiliation University of Sydney, Centre for Infectious Disease & Microbiology, Westmead Institute of Medical Research, Westmead, New South Wales, Australia
- Christopher M. Thomas
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Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: c.m.thomas@bham.ac.uk
Affiliation Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, England, United Kingdom
Competing Interests
The long-term aim of this work is to generate a commercially viable probiotic approach to displace multiresistance plasmids and is associated with University Spinout Plasgene of which CMT is sole director. The non-conjugative pCURE plasmids are protected by US Patent 12/299843 “Plasmid Curing” granted in 2014, owned by University of Birmingham Enterprise Ltd, U.K. The work described in this paper forms the basis of a new US Patent application (US62/879994) owned by University of Birmingham Enterprise Ltd, U.K. As current and former employees of the University of Birmingham CMT, CEM, ASH, JUK, ERS, GSL and MAW declare competing interests. CEM is currently employed by Birmingham Research Park Ltd but has not played a role in the work since moving to this position other than checking the accuracy of the manuscript. Since the mouse data is important for the development of pCURE JI and MK as employees of University of Sydney, Centre for Infectious Disease & Microbiology, Westmead Institute of Medical Research declare competing interests. The patented Mutaflor E. coli Nissle 1917 strain was provided by Ardeypharm GmbH free of charge for scientific purposes and cooperation. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.