About the Authors

Hikaru Ueno

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

hikaru.ueno@takeda.com

Current address: T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Ryo Ito

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Shin-ichi Abe

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Hitomi Ogino

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Minoru Maruyama

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Hirohisa Miyashita

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Yasufumi Miyamoto

Roles Conceptualization, Resources

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Yusuke Moritoh

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Research and Development Division, SCOHIA PHARMA Inc., Kanagawa, Japan

Yoshiyuki Tsujihata

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Koji Takeuchi

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Nobuhiro Nishigaki

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Cardiovascular Metabolic Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: This study was funded by Takeda Pharmaceutical Company Limited. During the time this study was conducted, HU, RI, SA, HO, MM, YMi, YT, KT and NN were the employees of Takeda, and YMo was an employee of SCOHIA PHARMA Inc. No other conflicts of interest to report exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.