Constitutive STAT5 phosphorylation in CD34+ cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity

Carlotta Abbà; Rita Campanelli; Paolo Catarsi; Laura Villani; Vittorio Abbonante; Melania Antonietta Sesta; Giovanni Barosi; Vittorio Rosti; Margherita Massa

doi:10.1371/journal.pone.0220189

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Peer-reviewed

Research Article

Constitutive STAT5 phosphorylation in CD34⁺ cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity

Carlotta Abbà,

Roles Data curation, Investigation, Validation

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Rita Campanelli,

Roles Data curation, Methodology

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Paolo Catarsi,

Roles Formal analysis, Investigation

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Laura Villani,

Roles Investigation, Resources

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Vittorio Abbonante,

Roles Resources, Validation

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy and Department of Molecular Medicine, University of Pavia, Pavia, Italy
⨯
Melania Antonietta Sesta,

Roles Investigation

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Giovanni Barosi,

Roles Conceptualization, Writing – review & editing

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Vittorio Rosti ,

Contributed equally to this work with: Vittorio Rosti, Margherita Massa

Roles Conceptualization, Project administration, Writing – original draft

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
⨯
Margherita Massa

Contributed equally to this work with: Vittorio Rosti, Margherita Massa

Roles Conceptualization, Formal analysis, Project administration, Writing – original draft

* E-mail: m.massa@smatteo.pv.it

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

http://orcid.org/0000-0001-8037-0439

⨯

Constitutive STAT5 phosphorylation in CD34⁺ cells of patients with primary myelofibrosis: Correlation with driver mutation status and disease severity

Carlotta Abbà,
Rita Campanelli,
Paolo Catarsi,
Laura Villani,
Vittorio Abbonante,
Melania Antonietta Sesta,
Giovanni Barosi,
Vittorio Rosti,
Margherita Massa

Published: August 1, 2019
https://doi.org/10.1371/journal.pone.0220189

About the Authors

Carlotta Abbà

Roles Data curation, Investigation, Validation

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Rita Campanelli

Roles Data curation, Methodology

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Paolo Catarsi

Roles Formal analysis, Investigation

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Laura Villani

Roles Investigation, Resources

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Vittorio Abbonante

Roles Resources, Validation

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy and Department of Molecular Medicine, University of Pavia, Pavia, Italy

Melania Antonietta Sesta

Roles Investigation

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Giovanni Barosi

Roles Conceptualization, Writing – review & editing

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Vittorio Rosti

Contributed equally to this work with: Vittorio Rosti, Margherita Massa

Roles Conceptualization, Project administration, Writing – original draft

Affiliation Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Margherita Massa

Contributed equally to this work with: Vittorio Rosti, Margherita Massa

Roles Conceptualization, Formal analysis, Project administration, Writing – original draft

* E-mail: m.massa@smatteo.pv.it

Affiliation Laboratory of Biochemistry, Biotechnology and Advanced Diagnosis, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

http://orcid.org/0000-0001-8037-0439

Competing Interests

The authors have declared that no competing interests exist.

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STAT signaling
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Phosphorylation
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Hemoglobin
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Cytokines
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Flow cytometry
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Deletion mutation
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Insertion mutation
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Variant genotypes
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