About the Authors

Alessandro Enrico Grimaldi

Roles Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

alessandro.grimaldi.sr@gmail.com

Affiliation MS Center Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

Laura De Giglio

Roles Investigation, Methodology, Supervision, Validation, Visualization

Affiliations MS Center Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy, Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Shalom Haggiag

Roles Investigation, Methodology, Resources, Supervision, Visualization

Affiliation Multiple Sclerosis Clinical Centre, San Camillo-Forlanini Hospital, Rome, Italy

Assunta Bianco

Roles Investigation, Methodology, Supervision, Visualization

Affiliation Multiple Sclerosis Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica, Rome, Italy

Antonio Cortese

Roles Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Sebastiano Giuseppe Crisafulli

Roles Investigation, Methodology, Supervision, Visualization

Affiliation Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Fabrizia Monteleone

Roles Investigation, Methodology, Supervision, Visualization

Affiliation MS Center, Department of Systems Medicine, Tor Vergata University, Rome, Italy

Gerola Marfia

Roles Investigation, Methodology, Supervision, Visualization

Affiliation MS Center, Department of Systems Medicine, Tor Vergata University, Rome, Italy

Luca Prosperini

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization

Affiliation Multiple Sclerosis Clinical Centre, San Camillo-Forlanini Hospital, Rome, Italy

Simonetta Galgani

Roles Investigation, Methodology, Resources, Supervision, Visualization

Affiliation Multiple Sclerosis Clinical Centre, San Camillo-Forlanini Hospital, Rome, Italy

Massimiliano Mirabella

Roles Investigation, Methodology, Supervision, Visualization

Affiliation Multiple Sclerosis Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica, Rome, Italy

Diego Centonze

Roles Investigation, Methodology, Resources, Validation, Visualization

Affiliations MS Center, Department of Systems Medicine, Tor Vergata University, Rome, Italy, Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Pozzilli, Italy

Carlo Pozzilli

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization

Affiliations MS Center Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy, Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Letizia Castelli

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization

Affiliation IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy

Competing Interests

De Giglio L received grants and personal fees from Novartis, Genzyme, Merck and Biogen. Haggiag S received speaking or travel fees from Biogen, Novartis, Genzyme, Eisai, CSL Behrig and Almirall. Monteleone F received personal fees or travel grants from Almirall, Biogen and Sanofi-Genzyme. Marfia G received personal fees from Almirall, Bayer Schering, Biogen Idec, Merck Serono, Novartis, Sanofi-Genzyme and Teva. Prosperini L received personal fees from Biogen, Teva, Almirall, Novartis, Genzyme, Roche and Merck Serono. Galgani S received personal fees from Biogen, Novartis, Genzyme, Almirall, Teva and Merck-Serono. Mirabella M received speaking fees, travel grants or research support from Almirall, Bayer Schering, Biogen, CSL Behring, Merck Serono, Novartis, Sanofi- Genzyme, Teva and Ultragenix. Centonze D received grants, personal fees or research support from Almirall, Bayer Schering, Biogen, GW Pharmaceuticals, Merck Serono, Novartis, Roche, Sanofi-Genzyme, Teva, Mitsubishi and Celgene. Pozzilli C reports grants and personal fees from Allergan, Almirall, Biogen, Genzyme, Hoffmann- La Roche Ltd, Merck Serono, Novartis, Sanofi and Teva. Castelli L received consulting fees from Almirall. The remaining authors have nothing to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.