Anticancer compound XL765 as PI3K/mTOR dual inhibitor: A structural insight into the inhibitory mechanism using computational approaches

Mohd Rehan

doi:10.1371/journal.pone.0219180

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Open Access

Peer-reviewed

Research Article

Anticancer compound XL765 as PI3K/mTOR dual inhibitor: A structural insight into the inhibitory mechanism using computational approaches

Mohd Rehan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mrehan786@gmail.com

Affiliations King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

http://orcid.org/0000-0003-4898-6043

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Anticancer compound XL765 as PI3K/mTOR dual inhibitor: A structural insight into the inhibitory mechanism using computational approaches

Mohd Rehan

Published: June 27, 2019
https://doi.org/10.1371/journal.pone.0219180

About the Authors

Mohd Rehan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mrehan786@gmail.com

Affiliations King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

http://orcid.org/0000-0003-4898-6043

Competing Interests

The authors have declared that no competing interests exist.

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Drug interactions
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Hydrogen bonding
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Cancers and neoplasms
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Library screening
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Molecular docking
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Binding analysis
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Pharmacokinetics
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