About the Authors

Kanita Salic

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation TNO, Department of Metabolic Health Research, Leiden, Netherlands

Robert Kleemann

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation TNO, Department of Metabolic Health Research, Leiden, Netherlands

Cynthia Wilkins-Port

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Current address: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Affiliation Shire LLC, now part of Takeda, Cambridge, Massachusetts, United States of America

John McNulty

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Shire LLC, now part of Takeda, Cambridge, Massachusetts, United States of America

Lars Verschuren

Roles Formal analysis, Writing – review & editing

Affiliation TNO, Department of Microbiology and Systems Biology, Zeist, Netherlands

Melissa Palmer

Roles Formal analysis, Writing – original draft, Writing – review & editing

melissa.palmer@takeda.com

Affiliation Shire LLC, now part of Takeda, Cambridge, Massachusetts, United States of America

Competing Interests

Melissa Palmer and John McNulty are employees of Shire, which is now part of Takeda, and own stock or stock options. Cynthia Wilkins-Port is a former employee of Shire and owns stock. Robert Kleemann, Lars Verschuren, and Kanita Salic are employees of TNO. This does not alter our adherence to PLOS ONE policies on sharing data and materials.