About the Authors

Willemijn S. M. E. Theelen

Contributed equally to this work with: Willemijn S. M. E. Theelen, Thomas Kuilman

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft

w.theelen@nki.nl

Affiliation Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Thomas Kuilman

Contributed equally to this work with: Willemijn S. M. E. Theelen, Thomas Kuilman

Roles Formal analysis, Writing – original draft

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Katja Schulze

Roles Data curation, Formal analysis, Resources, Writing – original draft

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America

Wei Zou

Roles Formal analysis

Affiliation Biostatistics, Genentech Inc., South San Francisco, United States of America

Oscar Krijgsman

Roles Formal analysis

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Dennis D. G. C. Peters

Roles Project administration, Resources, Writing – original draft

Affiliation Core Facility Molecular Pathology & Biobanking, Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Sten Cornelissen

Roles Project administration, Resources, Writing – review & editing

Affiliation Core Facility Molecular Pathology & Biobanking, Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Kim Monkhorst

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Division of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

Pranamee Sarma

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America

Teiko Sumiyoshi

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America

Lukas C. Amler

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America

Stefan M. Willems

Roles Resources

Affiliation Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands

Johannes L. G. Blaauwgeers

Roles Resources

Affiliation Department of Pathology, OLVG, Amsterdam, The Netherlands

Carel J. M. van Noesel

Roles Resources

Affiliation Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

Daniel S. Peeper

Roles Resources

‡ These authors also contributed equally to this work.

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Michel M. van den Heuvel

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Department of Pulmonology, Radboud University Medical Center, Nijmegen, The Netherlands

Marcin Kowanetz

Roles Conceptualization, Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America

Competing Interests

Willemijn SME Theelen: none. Thomas Kuilman: none. Katja Schulze: Genentech employee and holder of Roche stock. Wei Zou: Genentech employee and holder of Roche stock. Oscar Krijgsman: none. Dennis DGC Peters: none. Sten Cornelissen: none. Kim Monkhorst: personal fees from Roche, Pfizer, BMS, Abbvie, AstraZeneca, grants from AstraZeneca, non -financial support from Roche, non-financial support from Genentech outside the submitted work. Pranamee Sarma: Genentech employee and holder of Roche stock. Teiko Sumiyoshi: Genentech employee and holder of Roche stock Lukas C Amler: Genentech employee and holder of Roche stock. Stefan M Willems: medical advisor for and/or receives research grants from Roche, Pfizer, MDS, AstraZeneca, Cergentis, Merck Hans LG Blaauwgeers: none. Carel JM van Noesel: none. Daniel S Peeper: none. Michel M van den Heuvel: none Marcin Kowanetz: Genentech employee and holder of Roche stock. This does not alter our adherence to PLOS ONE policies on sharing data and materials.