About the Authors

Massoud Vosough

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Stem Cells and Developmental Biology, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Francesco Ravaioli

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy

Mihaela Zabulica

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Miriam Capri

Roles Writing – review & editing

Affiliations University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy, CIG, Interdepartmental Center ‘L. Galvani’, Alma Mater Studiorum, Bologna, Italy

Paolo Garagnani

Roles Writing – review & editing

Affiliations University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy, CIG, Interdepartmental Center ‘L. Galvani’, Alma Mater Studiorum, Bologna, Italy, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, CNR, Institute of Molecular Genetics, IGM, Unit. Bologna, Bologna, Italy

Claudio Franceschi

Roles Writing – review & editing

Affiliations University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Julie Piccand

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Nestlé Institute of Health Sciences, Stem Cells, Lausanne, Switzerland

Marine R.-C. Kraus

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Nestlé Institute of Health Sciences, Stem Cells, Lausanne, Switzerland

Kristina Kannisto

Roles Writing – review & editing

Affiliation Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Roberto Gramignoli

Roles Methodology, Writing – review & editing

Affiliation Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Stephen C. Strom

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

stephen.strom@ki.se

Affiliation Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Competing Interests

All authors declare no competing interest relevant to the submitted research. Research funding was provided entirely by EU FP7 grant HUMAN (Health and the Understanding of Metabolism, Aging and Nutrition)(grant agreement: 602757) and Vetenskaprådet (Swedish Research Council) and the Törsten and Ragnar Söderberg stiftelsen as indicated in the Amended Funding Statement. Nestlé SA does not hold any patent, product in development, or marketed product related to the research described in the manuscript. Nestlé Institute of Health Science (Nestlé S.A) employed authors Julie Piccand and Marie R. C. Kraus at the time of manuscript submission. Nestlé SA did not provide economical support for study design, data collection and analysis. JP and MK contributions are articulated in the “author contribution” section. Involvement of Nestlé SA in the research does not alter adherence to PLOS ONE policies on sharing data and methods.