About the Authors

Eisuke Shimizu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

ophthalmolog1st.acek39@keio.jp (ES); yoko@z7.keio.jp. (YO); tsubota@z3.keio.jp. (KT)

Affiliations Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, OUI Inc., Tokyo, Japan

Yoko Ogawa

Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

ophthalmolog1st.acek39@keio.jp (ES); yoko@z7.keio.jp. (YO); tsubota@z3.keio.jp. (KT)

Affiliation Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

Hiroyuki Yazu

Roles Data curation, Writing – review & editing

Affiliations Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, OUI Inc., Tokyo, Japan, Department of Ophthalmology, Tsurumi University School of Dental Medicine, Kanagawa, Japan

Naohiko Aketa

Roles Data curation, Writing – review & editing

Affiliations Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, OUI Inc., Tokyo, Japan

Fan Yang

Roles Methodology, Project administration, Writing – review & editing

Affiliations Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, Aier Eye School of Ophthalmology, Central South University, Tokyo, Japan

Mio Yamane

Roles Methodology, Project administration, Writing – review & editing

Affiliation Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

Yasunori Sato

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Department of Preventive Medicine and Public Health, Biostatistics at Clinical and Translational Research Center, Keio University School of Medicine, Tokyo, Japan

Yutaka Kawakami

Roles Supervision, Writing – review & editing

Affiliation Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University, Tokyo, Japan

Kazuo Tsubota

Roles Funding acquisition, Supervision, Writing – review & editing

ophthalmolog1st.acek39@keio.jp (ES); yoko@z7.keio.jp. (YO); tsubota@z3.keio.jp. (KT)

Affiliation Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

Competing Interests

Patent applied by OUI Inc. (Smart Eye Camera, PCT/JP2019/002824. Inventors ES, HY, and AN. Tokyo, Japan). There are no other relevant declarations relating this patent. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors declare no competing interest associated with this manuscript.