About the Authors

Ryosuke Nakano

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

Affiliations Research and Development Division, Kyowa Hakko Kirin Co., LTD., Machida-shi, Tokyo, Japan, Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan

Sayaka Takagi-Maeda

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Research and Development Division, Kyowa Hakko Kirin Co., LTD., Machida-shi, Tokyo, Japan

Yuji Ito

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan

Satoshi Kishimoto

Roles Data curation, Funding acquisition, Investigation, Methodology

Affiliation Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan

Tomoko Osato

Roles Funding acquisition, Methodology

Affiliation Research and Development Division, Kyowa Hakko Kirin Co., LTD., Machida-shi, Tokyo, Japan

Kaori Noguchi

Roles Funding acquisition, Methodology

Affiliation Research and Development Division, Kyowa Hakko Kirin Co., LTD., Machida-shi, Tokyo, Japan

Kana Kurihara-Suda

Roles Funding acquisition, Methodology

Affiliation Research and Development Division, Kyowa Hakko Kirin Co., LTD., Machida-shi, Tokyo, Japan

Nobuaki Takahashi

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

nobuaki.takahashi@kyowa-kirin.co.jp

Affiliation Research and Development Division, Kyowa Hakko Kirin Co., LTD., Chiyoda-ku, Tokyo, Japan

Competing Interests

We have the following interests Ryosuke Nakano, Sayaka Takagi-Maeda, Tomoko Osato, Kaori Noguchi, Kana Kurihara-Suda and Nobuaki Takahashi are employed by Kyowa Hakko Kirin Co., LTD.. The technology Accumubrain described in our manuscript was patented and published in June 2018 (Patent number WO2018123979). There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.