About the Authors

Axel Ducret

Roles Conceptualization, Data curation, Project administration, Supervision, Writing – original draft, Writing – review & editing

axel.ducret@roche.com

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

Ian James

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliation A4P Consulting Ltd, Sandwich, United Kingdom

Sabine Wilson

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Martina Feilke

Roles Data curation, Formal analysis, Visualization, Writing – original draft

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Andreas Tebbe

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Evotec (München) GmbH, Munich, Germany

Nikolaj Dybowski

Roles Data curation, Formal analysis, Software, Validation, Visualization

Affiliation Evotec (München) GmbH, Munich, Germany

Sarah Elschenbroich

Roles Formal analysis, Investigation, Methodology

Affiliation Evotec (München) GmbH, Munich, Germany

Martin Klammer

Roles Data curation, Formal analysis, Visualization

Affiliation Evotec (München) GmbH, Munich, Germany

Adele Blackler

Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision

Affiliation Oncoplex Diagnostics, Rockville, MD, United States of America

Wei-Li Liao

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Oncoplex Diagnostics, Rockville, MD, United States of America

Yuan Tian

Roles Formal analysis, Investigation, Methodology

Affiliation Oncoplex Diagnostics, Rockville, MD, United States of America

Thomas Friess

Roles Conceptualization, Supervision

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Birgit Bossenmaier

Roles Conceptualization, Investigation, Resources

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Gabriele Dietmann

Roles Conceptualization, Project administration, Resources

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Christoph Schaab

Roles Conceptualization, Project administration, Supervision

Affiliation Evotec (München) GmbH, Munich, Germany

Todd Hembrough

Roles Conceptualization, Project administration, Supervision

Affiliation Oncoplex Diagnostics, Rockville, MD, United States of America

Maurizio Ceppi

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Competing Interests

AD, SW, MF, TF, BB; GD, and MC are paid employees of Roche Pharma Research and EarlyDevelopment; AD, MC declare to own Roche shares; IJ is a paid employee of A4P Consulting Ltd and acts as a consultant for Roche Pharma Research and Early Development. AT, ND, SE, MK, and CS are paid employees of Evotec (München) GmbH; AB, W-LL, YT, and TH are paid employees of OncoplexDx, a fully owned subsidiary of NantOmics, and hold equities in NantOmics. In addition, TH declares to be a shareholder in NantHealth. Our commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.