About the Authors

Alpesh Amin

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

anamin@uci.edu

Affiliation University of California, Irvine, California, United States of America

Alessandra B. Garcia Reeves

Roles Conceptualization, Writing – review & editing

Affiliations University of North Carolina, Chapel Hill, North Carolina, United States of America, Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Xiaoyan Li

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Amol Dhamane

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Xuemei Luo

Roles Conceptualization, Writing – review & editing

Affiliation Pfizer, Inc., Groton, Connecticut, United States of America

Manuela Di Fusco

Roles Conceptualization, Writing – review & editing

Affiliation Pfizer Inc., New York, New York, United States of America

Anagha Nadkarni

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Keith Friend

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Lisa Rosenblatt

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America

Jack Mardekian

Roles Conceptualization, Writing – review & editing

Affiliation Pfizer Inc., New York, New York, United States of America

Xianying Pan

Roles Conceptualization, Writing – review & editing

Affiliation Bristol-Myers Squibb Company, Wallingford, Connecticut, United States of America

Huseyin Yuce

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation New York City College of Technology, City University of New York, New York, New York, United States of America

Allison Keshishian

Roles Conceptualization, Data curation, Writing – review & editing

Affiliations New York City College of Technology, City University of New York, New York, New York, United States of America, SIMR, Inc, Ann Arbor, Michigan, United States of America

Competing Interests

This study was funded by Bristol-Myers Squibb Company and Pfizer, Inc, both of whom are commercial companies. The funders provided support in the form of salaries for authors A.B.G.R., X. Li, A.D., K.F., X.P., L.R., A.N., X. Luo, M.D.F., and J.M. The funders also provided consultation fees for author A.K. of STATinMED Research which is a paid consultant to Pfizer and Bristol-Myers Squibb in connection with this study and the development of this manuscript. A.A. is an employee of University of California, Irvine and was a paid consultant to Bristol-Myers Squibb in connection with this study. ABGR is a research fellow of Bristol-Myers Squibb and a PhD candidate at the University of North Carolina, Chapel Hill. X Luo, M.D.F., and J.M. are paid employees of Pfizer Inc., with ownership of stocks in Pfizer Inc. H.Y. has nothing to disclose. However, the funders did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. There are no patents, products in development, or marketed products associated with this research to declare. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.