About the Authors

Marta Melis

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America

Xiao-Han Tang

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America

Steven E. Trasino

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America, School of Urban Public Health, Hunter College, City University of New York, New York, NY, United States of America

Viral M. Patel

Roles Formal analysis

Affiliation Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America

Daniel J. Stummer

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America

Jose Jessurun

Roles Formal analysis

Affiliation Department of Pathology, Weill Cornell Medicine, New York, NY, United States of America

Lorraine J. Gudas

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

ljgudas@med.cornell.edu

Affiliations Department of Pharmacology, Weill Cornell Medicine, New York, NY, United States of America, Weill Cornell Graduate School of Biomedical Sciences, New York, NY, United States of America

Competing Interests

Weill Cornell Medicine (WCM) has filed patents on some of the intellectual property in this manuscript and these were licensed to Sveikatal, Inc. LJG and XHT are founders and have financial interests in Sveikatal, Inc. SET is an inventor on the intellectual property (IP) owned by WCM. MM, VMP, DJS and JJ report no conflicts of interest associated with this publication. This does not alter our adherence to PLOS ONE policies on sharing data and materials. • US20180263924A1 "Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists” • US10010512B2"Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid receptor agonists”.