About the Authors

Andrew Y. F. Li Yim

Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

Roles Data curation, Formal analysis, Software, Visualization, Writing – original draft

Affiliations Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands, Epigenetics Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

Jessica R. de Bruyn

Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

Roles Investigation, Writing – original draft

Affiliations Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands, Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Nicolette W. Duijvis

Contributed equally to this work with: Andrew Y. F. Li Yim, Jessica R. de Bruyn, Nicolette W. Duijvis

Roles Investigation, Writing – original draft

Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Catriona Sharp

Roles Supervision, Writing – review & editing

Affiliation Epigenetics Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom

Enrico Ferrero

Roles Supervision, Writing – review & editing

Current address: Autoimmunity Transplantation and Inflammation Bioinformatics, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Affiliation Computational Biology, Target Sciences, GlaxoSmithKline, Stevenage, United Kingdom

Wouter J. de Jonge

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Manon E. Wildenberg

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Marcel M. A. M. Mannens

Roles Supervision, Writing – review & editing

Affiliation Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Christianne J. Buskens

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Geert R. D’Haens

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Peter Henneman

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

‡ These authors are joint senior authors on this work.

Affiliation Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Anje A. te Velde

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

a.a.tevelde@amc.nl

‡ These authors are joint senior authors on this work.

Affiliation Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Competing Interests

We have the following interests: GlaxoSmithKline provided support in the form of salaries for authors AYFLY and CS and GlaxoSmithKline and Novartis provided support in the form of salaries for author EF. WJJ was financially supported by GlaxoSmithKline, Maed Johnsson, Schwabe (aforementioned funds were unrelated to this study) and was a co-owner of Gut Research BV at the time of writing this manuscript. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.