About the Authors

Tina Xiong

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Dahlia Rohm

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Rachael E. Workman

Roles Investigation

Affiliation Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Lauren Roundtree

Roles Investigation

Affiliation Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Carl D. Novina

Roles Funding acquisition, Writing – review & editing

Affiliations Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Winston Timp

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Marc Ostermeier

Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

oster@jhu.edu

Affiliation Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

TX, CDN, and MO are inventors on a patent application (US Patent Application 15/539256 Systems and methods for genome modification and regulation), which is related to the experiments found in this manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.