About the Authors

Kerstin Pohl

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, National Jewish Health, Denver, CO, United States of America

David P. Nichols

Roles Supervision, Writing – review & editing

Affiliation Department of Pediatrics, University of Washington, Seattle, WA, United States of America

Jennifer L. Taylor-Cousar

Roles Supervision, Writing – review & editing

Affiliations Department of Medicine, National Jewish Health, Denver, CO, United States of America, Department of Pediatrics, National Jewish Health, Denver, CO, United States of America, University of Colorado School of Medicine, Aurora, CO, United States of America

Milene T. Saavedra

Roles Methodology, Supervision, Writing – review & editing

Affiliations Department of Medicine, National Jewish Health, Denver, CO, United States of America, University of Colorado School of Medicine, Aurora, CO, United States of America

Matthew J. Strand

Roles Methodology, Resources, Supervision, Writing – review & editing

Affiliation Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, United States of America

Jerry A. Nick

Contributed equally to this work with: Jerry A. Nick, Preston E. Bratcher

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Medicine, National Jewish Health, Denver, CO, United States of America, University of Colorado School of Medicine, Aurora, CO, United States of America

Preston E. Bratcher

Contributed equally to this work with: Jerry A. Nick, Preston E. Bratcher

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

bratcherp@njhealth.org

Affiliation Department of Pediatrics, National Jewish Health, Denver, CO, United States of America

Competing Interests

DPN has received grant funding from Vertex Pharmaceuticals. JLT has received grant funding from Vertex Pharmaceuticals, Gilead, Bayer, Proteostasis, and Novalis, reports personal fees from participation in advisory boards for Vertex Pharmaceuticals, Gilead, Novartis, Genentech and Proteostasis, and reports personal fees for speaking on behalf of Vertex Pharmaceuticals and Gilead. Commercial funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.