About the Authors

Toshihiko Kumazawa

Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

Affiliations Ichibiki CO., LTD. Nagoya, Japan, Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Atsuhisa Nishimura

Roles Conceptualization, Data curation, Project administration, Writing – review & editing

Affiliation Ichibiki CO., LTD. Nagoya, Japan

Noriyuki Asai

Roles Conceptualization, Methodology, Resources

Affiliation Ichibiki CO., LTD. Nagoya, Japan

Takahiro Adachi

Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft

tadachi.imm@mri.tmd.ac.jp

Affiliation Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Competing Interests

This study was financially supported by Ichibiki CO., LTD. (http://www.ichibiki.co.jp/). T.K. A.N. and N.A. are employees of Ichibiki CO., LTD. The heat-killed LAB strains used for this study were provided by Ichibiki CO., LTD. We have applied for a patent on a modal halotolerance LAB and the cultivation (WO2018/047979), and in Japan, a patent was acquired (Japanese patent No. 6337262), and T. halophilus strain No.1 was commercialized under T. halophilus strain KURAHANA LTK-1 by Ichibiki CO., LTD. These does not alter our adherence to PLOS ONE policies on sharing data and materials.