About the Authors

Elizabeth A. Pearsall

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Angiogenesis Laboratory, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, United States, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

Rui Cheng

Roles Data curation, Funding acquisition, Methodology, Writing – review & editing

Affiliation Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

Satoshi Matsuzaki

Roles Formal analysis, Investigation

Affiliation Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States

Kelu Zhou

Roles Investigation, Methodology

Affiliation Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

Lexi Ding

Roles Investigation, Methodology

Affiliation Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

Bumsoo Ahn

Roles Investigation

Affiliation Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States

Michael Kinter

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States

Kenneth M. Humphries

Roles Conceptualization, Funding acquisition, Methodology

Affiliations Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States, Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

Alexander B. Quiambao

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation EyeCRO LLC, Oklahoma City, OK, United States

Rafal A. Farjo

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation EyeCRO LLC, Oklahoma City, OK, United States

Jian-xing Ma

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

jian-xing-ma@ouhsc.edu

Affiliations Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, Harold Hamm Oklahoma Diabetes Center, Oklahoma City, OK, United States

Competing Interests

We note that two of the authors, Alexander B. Quiambao and Rafal A. Farjo are Employed by a commercial company, EyeCRO LLC. EyeCRO did not play a role in study design, data collection and analysis, preparation of the manuscript, or decision to publish the manuscript. The only financial support provided was for the authors’ salaries. This affiliation does not alter our adherence to PLOS ONE policies regarding sharing data and materials, and the raw data is now available on the Harvard Dataverse. There are no patents, products in development or marketed products related to this work.