About the Authors

Marcia Cristina T. dos Santos

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Translational Medicine, UCB Biopharma SPRL, Braine L’Alleud, Belgium

Dieter Scheller

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliation Consultancy Neuropharm, Neuss, Germany

Claudia Schulte

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, University of Tuebingen and German Center for Neurodegenerative Diseases, Tuebingen, Germany

Irene R. Mesa

Roles Formal analysis, Software, Validation, Writing – review & editing

Affiliation Exploratory Statistics, Global Exploratory Development, UCB Pharma SA, Slough, United Kingdom

Peter Colman

Roles Data curation, Formal analysis

Affiliation Exploratory Statistics, Global Exploratory Development, UCB Pharma SA, Slough, United Kingdom

Sarah R. Bujac

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Exploratory Statistics, Global Exploratory Development, UCB Pharma SA, Slough, United Kingdom

Rosie Bell

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation

Current address: Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom.

Affiliation Translational Medicine, UCB Biopharma SPRL, Braine L’Alleud, Belgium

Caroline Berteau

Roles Investigation, Methodology

Current address: Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.

Affiliation Translational Medicine, UCB Biopharma SPRL, Braine L’Alleud, Belgium

Luis Tosar Perez

Roles Methodology

Affiliation Bioanalytical Sciences, Non Clinical Development, UCB Biopharma SPRL, Braine L’Alleud, Belgium

Ingolf Lachmann

Roles Methodology

Affiliation Research and Development, Analytik Jena, Jena, Germany

Daniela Berg

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliations Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, University of Tuebingen and German Center for Neurodegenerative Diseases, Tuebingen, Germany, Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany

Walter Maetzler

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliations Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, University of Tuebingen and German Center for Neurodegenerative Diseases, Tuebingen, Germany, Department of Neurology, Christian-Albrechts-University Kiel, Kiel, Germany

Andre Nogueira da Costa

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

andre.dacosta@ucb.com

Affiliation Translational Medicine, UCB Biopharma SPRL, Braine L’Alleud, Belgium

Competing Interests

We have the following interests. Marcia Cristina T. dos Santos, Rosie Bell, Andre Nogueira da Costa, Luis Tosar Perez and Caroline Berteau are employed by UCB Biopharma SPRL, Dieter Scheller by Consultancy Neuropharm, Irene R. Mesa Peter Colman and Sarah R. Bujac by UCB Pharma SA and Ingolf Lachmann by Analytik Jena. This study was partly funded by UCB Pharma GmbH. IRM and ANdC have share options from UCB Biopharma SPRL and PC has share options from UCB Biopharma SPRL. DB is a full professor at Kiel University and the director of the Department of Neurology at UKSH, Campus Kiel. She has served on scientific advisory boards for Novartis, UCB/ SCHWARZ PHARMA, Lundbeck, and Teva Pharmaceutical Industries Ltd.; has received funding for travel or speaker honoraria from Boehringer Ingelheim, Lundbeck Inc., Novartis GlaxoSmithKline, UCB/ SCHWARZ PHARMA, Merck Serono, Johnson & Johnson, and Teva Pharmaceutical Industries Ltd.; and has received research support from Janssen, Teva Pharmaceutical Industries Ltd., Solvay Pharmaceuticals, Inc./Abbott, Boehringer, UCB, Michael J Fox Foundation, BMBF, dPV (German Parkinson’s disease association), Neuroallianz, DZNE and the Center of Integrative Neurosciences. WM is a full professor at Kiel University. He received and receives funding from the European Union, the Michael J. Fox Foundation, Robert Bosch Foundation, Neuroalliance, Lundbeck and Janssen, and holds part of a patent for the assessment of dyskinesias (German patent office, 102015220741.2). He received speaker honoraria from GlaxoSmithKline, Abbvie, UCB, Licher. MT and Rölke Pharma, and was invited to Advisory Boards of Market Access & Pricing Strategy GmbH and Abbvie. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.