About the Authors

Danielle van Keulen

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands, Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands, Quorics B.V, Rotterdam, The Netherlands, TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands

Marianne G. Pouwer

Roles Investigation, Writing – review & editing

Affiliations TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

Gerard Pasterkamp

Roles Supervision, Writing – review & editing

Affiliations Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands, Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands

Alain J. van Gool

Roles Project administration, Supervision, Writing – review & editing

Affiliations TNO- Microbiology & Systems Biology, Zeist, The Netherlands, Radboudumc, Nijmegen, The Netherlands

Maarten D. Sollewijn Gelpke

Roles Project administration, Writing – review & editing

Affiliation Molecular Profiling Consulting, London, England

Hans M. G. Princen

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands

Dennie Tempel

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

d.tempel@umcutrecht.nl

Affiliations Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands, Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands, Quorics B.V, Rotterdam, The Netherlands

Competing Interests

The authors have the following interests. Danielle van Keulen and Dennie Tempel are employed by Quorics B.V. and Maarten D Sollewijn Gelpke by Molecular Profiling Consulting. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.