About the Authors

Masako Fujiwara

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Writing – original draft

fmasako@m.tohoku.ac.jp

Affiliation Department of Planning for Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

Itiro Ando

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Planning for Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

Keisuke Satoh

Roles Data curation, Resources

Affiliation Koujikai Nagamachi Clinic, Sendai, Miyagi, Japan

You Shishido

Roles Investigation, Supervision

Affiliation Midorinosato Clinic, Iwanuma, Miyagi, Japan

Kazuhito Totsune

Roles Validation, Writing – review & editing

Affiliation Department of Planning for Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

Hiroshi Sato

Roles Funding acquisition, Supervision

Affiliation Laboratory of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

Yutaka Imai

Roles Supervision, Writing – review & editing

Affiliations Department of Planning for Drug Development and Clinical Evaluation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan, Tohoku Institute for Management of Blood Pressure, Sendai, Miyagi, Japan

Competing Interests

Two of our authors [KS, YS], are employed by a commercial company: "Koujikai Nagamachi Clinic and Midorinosato Clinic", respectively. These funders provided support in the form of salaries for authors [KS, YS], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.