About the Authors

Tadamichi Akagi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

Linda M. Zangwill

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Takuhei Shoji

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliations Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America, Department of Ophthalmology, Saitama Medical University, Saitama, Japan

Min Hee Suh

Roles Data curation, Investigation, Validation

Affiliations Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America, Department of Ophthalmology, Haeundae Paik Hospital, Inje University, Busan, South Korea

Luke J. Saunders

Roles Formal analysis, Validation

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Adeleh Yarmohammadi

Roles Data curation, Validation

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Patricia Isabel C. Manalastas

Roles Data curation, Validation

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Rafaella C. Penteado

Roles Data curation, Validation

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Robert N. Weinreb

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

rweinreb@ucsd.edu

Affiliation Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States of America

Competing Interests

This study was funded by National Eye Institute grants: EY029058 (RNW), EY011088 (LMZ), EY014267 (LMZ), EY019689 (LMZ), Core Grant P30EY022589 (LMZ); an unrestricted grant from Research to Prevent Blindness (RNW), grants for participants’ glaucoma medications from Alcon, Allergan, Pfizer, Merck and Santen (RNW) and the John Mung Program from Kyoto University Global Frontier Project for Young Professionals (TA). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.