About the Authors

Damien Coté

Contributed equally to this work with: Damien Coté, Alex Eustace

Roles Formal analysis, Validation, Writing – original draft, Writing – review & editing

DamienCote@rcsi.ie

Affiliation Royal College of Surgeons in Ireland, Data Science Centre, Dublin, Ireland

Alex Eustace

Contributed equally to this work with: Damien Coté, Alex Eustace

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Dublin City University, National Institute for Cellular Biotechnology, Molecular Therapeutics for Cancer in Ireland, Dublin, Ireland

Sinead Toomey

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

Mattia Cremona

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

Malgorzata Milewska

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

Simon Furney

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Physiology and Medical Physics, Dublin, Ireland

Aoife Carr

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland

Joanna Fay

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Pathology, Dublin, Ireland

Elaine Kay

Roles Methodology, Writing – review & editing

Affiliation Royal College of Surgeons in Ireland, Department of Pathology, Dublin, Ireland

Susan Kennedy

Roles Investigation, Writing – review & editing

Affiliation St Vincent’s University Hospital, Medical Oncology, Dublin, Ireland

John Crown

Roles Investigation, Writing – review & editing

Affiliations Dublin City University, National Institute for Cellular Biotechnology, Molecular Therapeutics for Cancer in Ireland, Dublin, Ireland, St Vincent’s University Hospital, Medical Oncology, Dublin, Ireland

Bryan Hennessy

Roles Investigation, Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliations Royal College of Surgeons in Ireland, Department of Molecular Medicine, Medical Oncology Group, Dublin, Ireland, Beaumont Hospital, Department of Medical Oncology, Dublin, Ireland

Stephen Madden

Roles Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Royal College of Surgeons in Ireland, Data Science Centre, Dublin, Ireland

Competing Interests

The TCHL clinical study was sponsored by Cancer Trials Ireland (formerly known as the Irish Clinical Oncology Research Group [ICORG]), which received funding from GlaxoSmithKline. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.