About the Authors

Mariko Tani

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Nutrition in Cardiovascular Disease, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

Yuko Kamata

Roles Investigation

Affiliation Department of Life sciences and Bioethics, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

Michiyo Deushi

Roles Investigation

Affiliation Department of Life sciences and Bioethics, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

Mizuko Osaka

Roles Funding acquisition, Writing – review & editing

Affiliations Department of Nutrition in Cardiovascular Disease, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan, Department of Life sciences and Bioethics, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

Masayuki Yoshida

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

masa.vasc@tmd.ac.jp

Affiliation Department of Life sciences and Bioethics, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

Competing Interests

MSD K.K. and Mitsubishi Tanabe Pharma Corporation provided support in the form of salaries for author MT. Research grant for this work was provided by Astellas Pharma Inc (MT and MY), Takeda Pharmaceutical Company Limited (MY), Daiichi Sankyo Company Limited (MY), MSD K.K. (MY), Boehringer Ingelheim Japan, Inc. (MY), and AstraZeneca (MY). The sponsors had no control over the study design, data collection, interpretation, writing, or publication of this work. The authors have no conflicts of interest directly relevant to the content of this article. This does not alter our adherence to PLOS ONE policies on sharing data and materials.