About the Authors

Alexey Ruzin

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

ruzina@medimmune.com

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Susan T. Pastula

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Epidstat Institute, Ann Arbor, Michigan, United States of America

Elizabeth Levin-Sparenberg

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Epidstat Institute, Ann Arbor, Michigan, United States of America

Xiaohui Jiang

Roles Data curation, Formal analysis

Affiliation Epidstat Institute, Ann Arbor, Michigan, United States of America

Jon Fryzek

Roles Formal analysis, Methodology, Supervision

Affiliation Epidstat Institute, Ann Arbor, Michigan, United States of America

Andrey Tovchigrechko

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Bin Lu

Roles Formal analysis, Project administration, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Mountain View, California, United States of America

Yanping Qi

Roles Formal analysis, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Mountain View, California, United States of America

Hui Liu

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Mountain View, California, United States of America

Hong Jin

Roles Formal analysis, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Mountain View, California, United States of America

Li Yu

Roles Conceptualization, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Judith Hackett

Roles Formal analysis, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Tonya Villafana

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Mark T. Esser

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation AstraZeneca/MedImmune, Gaithersburg, Maryland, United States of America

Competing Interests

This work was sponsored by AstraZeneca/MedImmune. AR, AT, BL, YQ, HL, HJ, LY, JH, TV, and ME are employees and stockholders of AstraZeneca/MedImmune. SP, EL-S, XJ, and JF are employees of EpidStat Institute, which is a research institute that provides expert assistance on the evaluation of complex health issues and on the conduct and interpretation of epidemiological studies to pharmaceutical and medical device companies, and are paid consultants to AstraZeneca. ME, AR, HL, and LY (AstraZeneca/MedImmune) conceptualized the study design and set up data collection. XJ, SP, EL-S, JF, ME, AR, BL, YQ, HL, AT, HJ, JH, and TV made contributions to the analysis and interpretation of the data (AstraZeneca/MedImmune and EpidStat). SP, EL-S, ME, AR, and TV (AstraZeneca/MedImmune and EpidStat) drafted the manuscript and, along with BL, HJ, YQ, JH, (AstraZeneca/MedImmune) critically revised the manuscript. ME, AR, LY, TV, AT, SP, EL-S, and JF (AstraZeneca/MedImmune and EpidStat) were active participants in discussions regarding the development of the manuscript and decision to publish. This does not alter our adherence to PLOS ONE policies on sharing data and materials. AstraZeneca/Medimmune and Epidstat had no direct roles in study design, data collection, analysis, manuscript development or revision.