MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy

Evaldas Girdauskas; Johannes Petersen; Niklas Neumann; Martin Ungelenk; Ingo Kurth; Hermann Reichenspurner; Tanja Zeller

doi:10.1371/journal.pone.0200205

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Open Access

Peer-reviewed

Research Article

MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy

Evaldas Girdauskas ,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: e.girdauskas@uke.de

Affiliations Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
⨯
Johannes Petersen,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
⨯
Niklas Neumann,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
⨯
Martin Ungelenk,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Institute of Human Genetics, Friedrich-Schiller University Hospital Jena, Jena, Germany
⨯
Ingo Kurth,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Institute of Human Genetics, University Hospital RWTH Aachen, Aachen, Germany
⨯
Hermann Reichenspurner,

Roles Data curation, Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany
⨯
Tanja Zeller

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany, Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany

http://orcid.org/0000-0003-3379-2641

⨯

MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy

Evaldas Girdauskas,
Johannes Petersen,
Niklas Neumann,
Martin Ungelenk,
Ingo Kurth,
Hermann Reichenspurner,
Tanja Zeller

Published: July 30, 2018
https://doi.org/10.1371/journal.pone.0200205

About the Authors

Evaldas Girdauskas

Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: e.girdauskas@uke.de

Affiliations Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Johannes Petersen

Roles Data curation, Methodology, Writing – review & editing

Niklas Neumann

Roles Data curation, Methodology, Writing – review & editing

Martin Ungelenk

Roles Data curation, Methodology, Writing – review & editing

Affiliation Institute of Human Genetics, Friedrich-Schiller University Hospital Jena, Jena, Germany

Ingo Kurth

Roles Data curation, Methodology, Writing – review & editing

Affiliation Institute of Human Genetics, University Hospital RWTH Aachen, Aachen, Germany

Hermann Reichenspurner

Roles Data curation, Funding acquisition, Supervision, Writing – review & editing

Tanja Zeller

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany, Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany

http://orcid.org/0000-0003-3379-2641

Competing Interests

The authors have declared that no competing interests exist.

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MicroRNAs
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Human genetics
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Aortic valve
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Blood
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Notch signaling
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Surgical and invasive medical procedures
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Gene identification and analysis
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Genetic linkage
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