About the Authors

Salvatore Rinaldi

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

srinaldi@irf.it

Affiliations Research Department, Rinaldi Fontani Foundation, Florence, Italy, Department of Regenerative and Anti-Aging Medicine, Rinaldi Fontani Institute, Florence, Italy, IRF Shanghai Medical Sciences, Shanghai, China

Maria Antonia Meloni

Contributed equally to this work with: Maria Antonia Meloni, Grazia Galleri

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

Affiliation Research Department, Rinaldi Fontani Foundation, Florence, Italy

Grazia Galleri

Contributed equally to this work with: Maria Antonia Meloni, Grazia Galleri

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliation Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy

Margherita Maioli

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliations Department of Regenerative and Anti-Aging Medicine, Rinaldi Fontani Institute, Florence, Italy, IRF Shanghai Medical Sciences, Shanghai, China, Department of Biomedical Sciences, University of Sassari, Sassari, Italy, Genetics and Biomedical Research Institute, National Research Council (CNR), Monserrato, Cagliari, Italy

Gianfranco Pigliaru

Roles Data curation, Investigation, Visualization

Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, Genetics and Biomedical Research Institute, National Research Council (CNR), Monserrato, Cagliari, Italy

Giulia Cugia

Roles Data curation, Investigation, Visualization

Affiliation ViroStatic S.r.l., Alghero, Italy

Sara Santaniello

Roles Data curation, Investigation, Visualization

Affiliations Department of Biomedical Sciences, University of Sassari, Sassari, Italy, Genetics and Biomedical Research Institute, National Research Council (CNR), Monserrato, Cagliari, Italy

Alessandro Castagna

Roles Data curation, Investigation, Visualization

Affiliation Department of Regenerative and Anti-Aging Medicine, Rinaldi Fontani Institute, Florence, Italy

Vania Fontani

Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliations Research Department, Rinaldi Fontani Foundation, Florence, Italy, Department of Regenerative and Anti-Aging Medicine, Rinaldi Fontani Institute, Florence, Italy, IRF Shanghai Medical Sciences, Shanghai, China

Competing Interests

Salvatore Rinaldi and Vania Fontani invented REAC technology. Giulia Cugia is affiliated with the commercial organization Virostatic s.r.l., Alghero, Italy. This does not alter our adherence to PLOS ONE policies on sharing data and materials.