About the Authors

Cheleste M. Thorpe

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

cthorpe@tuftsmedicalcenter.org

Affiliations Tufts Medical Center, Boston, MA, United States of America, Tufts University School of Medicine, Boston, MA, United States of America

Anne V. Kane

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Tufts Medical Center, Boston, MA, United States of America

Justin Chang

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Tufts University School of Medicine, Boston, MA, United States of America

Albert Tai

Roles Formal analysis, Resources

Affiliation Tufts University School of Medicine, Boston, MA, United States of America

Richard J. Vickers

Roles Conceptualization, Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Summit Therapeutics Plc, Abingdon, Oxfordshire, United Kingdom

David R. Snydman

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Tufts Medical Center, Boston, MA, United States of America, Tufts University School of Medicine, Boston, MA, United States of America

Competing Interests

The sponsor of the study was Summit Therapeutics Plc. (http://www.summitplc.com/), who received a Wellcome Trust Translation Award (Grant Number 099444; https://wellcome.ac.uk/) in support of the study. CMT and DRS have received research grants from Summit Therapeutics Plc., Actelion (https://www1.actelion.us/us/index.page), and Merck (http://www.merck.com/index.html). CMT has been on an Advisory Board for Summit Therapeutics Plc. AVK has received research grants and a travel grant from Summit Therapeutics Plc. RJV is an employee of, and holds share options in, Summit Therapeutics. RJV was involved in study design and analysis of data as well as preparation of, and decision to publish the manuscript. JC and AT have no competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.