About the Authors

Mary F. Feitosa

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

mfeitosa@wustl.edu (MFF); levyD@nih.gov (DL)

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Aldi T. Kraja

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Daniel I. Chasman

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Yun J. Sung

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Thomas W. Winkler

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

Ioanna Ntalla

Contributed equally to this work with: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Xiuqing Guo

Roles Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

Nora Franceschini

Roles Formal analysis, Writing – review & editing

Affiliation Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina, United States of America

Ching-Yu Cheng

Roles Funding acquisition, Supervision

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Xueling Sim

Roles Data curation, Formal analysis, Supervision

Affiliation Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore

Dina Vojinovic

Roles Formal analysis, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Jonathan Marten

Roles Data curation

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Solomon K. Musani

Roles Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization

Affiliation Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Changwei Li

Roles Formal analysis

Affiliation Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, United States of America

Amy R. Bentley

Roles Conceptualization, Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Michael R. Brown

Roles Data curation, Formal analysis, Funding acquisition, Software

Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Karen Schwander

Roles Formal analysis, Writing – review & editing

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Melissa A. Richard

Roles Formal analysis, Writing – review & editing

Affiliation Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Raymond Noordam

Roles Formal analysis, Writing – review & editing

Affiliation Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

Hugues Aschard

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France

Traci M. Bartz

Roles Formal analysis, Writing – review & editing

Affiliation Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, United States of America

Lawrence F. Bielak

Roles Data curation, Formal analysis, Software, Writing – review & editing

Affiliation Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Rajkumar Dorajoo

Roles Data curation, Formal analysis

Affiliation Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

Virginia Fisher

Roles Formal analysis

Affiliation Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Fernando P. Hartwig

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

Andrea R. V. R. Horimoto

Roles Formal analysis, Investigation

Affiliation Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil

Kurt K. Lohman

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Alisa K. Manning

Roles Writing – review & editing

Affiliations Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Tuomo Rankinen

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Albert V. Smith

Roles Data curation, Formal analysis, Investigation, Validation

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Salman M. Tajuddin

Roles Data curation, Formal analysis

Affiliation Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Mary K. Wojczynski

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Maris Alver

Roles Data curation, Formal analysis, Investigation

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Mathilde Boissel

Roles Data curation, Formal analysis

Affiliation CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France

Qiuyin Cai

Roles Data curation, Investigation, Validation

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Archie Campbell

Roles Data curation

Affiliation Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Jin Fang Chai

Roles Data curation, Formal analysis

Affiliation Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore

Xu Chen

Roles Formal analysis

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden

Jasmin Divers

Roles Formal analysis, Writing – review & editing

Affiliation Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Chuan Gao

Roles Formal analysis, Writing – review & editing

Affiliation Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Anuj Goel

Roles Formal analysis, Project administration, Resources, Writing – review & editing

Affiliations Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom

Yanick Hagemeijer

Roles Data curation, Investigation

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Sarah E. Harris

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom, Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom

Meian He

Roles Formal analysis, Funding acquisition, Validation, Writing – review & editing

Affiliation Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Fang-Chi Hsu

Roles Formal analysis, Writing – review & editing

Affiliation Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Anne U. Jackson

Roles Formal analysis

Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Mika Kähönen

Roles Investigation, Resources, Writing – review & editing

Affiliations Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland, University of Tampere, Tampere, Finland

Anuradhani Kasturiratne

Roles Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

Pirjo Komulainen

Roles Investigation, Project administration, Resources

Affiliation Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

Brigitte Kühnel

Roles Formal analysis, Writing – review & editing

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Federica Laguzzi

Roles Data curation, Formal analysis, Software, Validation, Writing – review & editing

Affiliation Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Jian'an Luan

Roles Formal analysis

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Nana Matoba

Roles Validation

Affiliation Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Ilja M. Nolte

Roles Formal analysis, Writing – review & editing

Affiliation Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Sandosh Padmanabhan

Roles Data curation

Affiliation Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

Muhammad Riaz

Roles Formal analysis, Writing – review & editing

Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Rico Rueedi

Roles Data curation, Formal analysis, Software

Affiliations Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, Swiss Instititute of Bioinformatics, Lausanne, Switzerland

Antonietta Robino

Roles Formal analysis

Affiliation Institute for Maternal and Child Health—IRCCS "Burlo Garofolo", Trieste, Italy

M. Abdullah Said

Roles Data curation, Investigation

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Robert A. Scott

Roles Formal analysis

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Tamar Sofer

Roles Methodology, Supervision, Writing – review & editing

Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America

Alena Stančáková

Roles Data curation, Investigation, Writing – review & editing

Affiliation Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

Fumihiko Takeuchi

Roles Formal analysis

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Bamidele O. Tayo

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, United States of America

Peter J. van der Most

Roles Formal analysis, Writing – review & editing

Affiliation Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Tibor V. Varga

Roles Formal analysis, Writing – review & editing

Affiliation Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden

Veronique Vitart

Roles Data curation

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Yajuan Wang

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Erin B. Ware

Roles Data curation, Formal analysis, Project administration, Validation, Writing – review & editing

Affiliation Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America

Helen R. Warren

Roles Data curation, Formal analysis, Validation

Affiliations Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom

Stefan Weiss

Roles Formal analysis

Affiliations Interfaculty Institute for Genetics and Functional genomics, University Medicine Ernst Moritz Arndt University Greifsald, Greifswald, Germany, DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Wanqing Wen

Roles Formal analysis

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Lisa R. Yanek

Roles Data curation, Formal analysis, Project administration

Affiliation Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Weihua Zhang

Roles Formal analysis, Software

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom

Jing Hua Zhao

Roles Formal analysis

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Saima Afaq

Roles Formal analysis

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Najaf Amin

Roles Resources, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Marzyeh Amini

Roles Resources, Writing – review & editing

Affiliation Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Dan E. Arking

Roles Data curation, Formal analysis

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Tin Aung

Roles Funding acquisition

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Eric Boerwinkle

Roles Conceptualization, Funding acquisition, Resources

Affiliations Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, United States of America, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Ingrid Borecki

Roles Conceptualization, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Ulrich Broeckel

Roles Writing – review & editing

Affiliation Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Morris Brown

Roles Funding acquisition, Investigation

Affiliations Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom

Marco Brumat

Roles Formal analysis

Affiliation Department of Medical Sciences, University of Trieste, Trieste, Italy

Gregory L. Burke

Roles Funding acquisition, Investigation, Project administration

Affiliation Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Mickaël Canouil

Roles Data curation, Formal analysis, Supervision

Affiliation CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France

Aravinda Chakravarti

Roles Data curation, Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Sabanayagam Charumathi

Roles Funding acquisition

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore

Yii-Der Ida Chen

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

John M. Connell

Roles Project administration, Resources

Affiliation Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom

Adolfo Correa

Roles Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Lisa de las Fuentes

Roles Formal analysis, Writing – review & editing

Affiliations Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, United States of America

Renée de Mutsert

Roles Data curation, Project administration, Writing – review & editing

Affiliation Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

H. Janaka de Silva

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation

Affiliation Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

Xuan Deng

Roles Formal analysis

Affiliation Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Jingzhong Ding

Roles Investigation, Writing – review & editing

Affiliation Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

Qing Duan

Roles Formal analysis

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Charles B. Eaton

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Georg Ehret

Roles Data curation, Funding acquisition

Affiliation Cardiology, Geneva University Hospital, Geneva, Switzerland

Ruben N. Eppinga

Roles Data curation, Investigation

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Evangelos Evangelou

Roles Data curation, Formal analysis

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

Jessica D. Faul

Roles Data curation, Formal analysis, Project administration

Affiliation Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America

Stephan B. Felix

Roles Writing – review & editing

Affiliations DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

Nita G. Forouhi

Roles Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Terrence Forrester

Roles Investigation

Affiliation The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica

Oscar H. Franco

Roles Investigation, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Yechiel Friedlander

Roles Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Ilaria Gandin

Roles Formal analysis

Affiliation Department of Medical Sciences, University of Trieste, Trieste, Italy

He Gao

Roles Formal analysis

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Mohsen Ghanbari

Roles Investigation, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Bruna Gigante

Roles Resources, Writing – review & editing

Affiliation Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

C. Charles Gu

Roles Formal analysis, Writing – review & editing

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Dongfeng Gu

Roles Data curation

Affiliation Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Saskia P. Hagenaars

Roles Formal analysis, Writing – review & editing

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom, Psychology, The University of Edinburgh, Edinburgh, United Kingdom

Göran Hallmans

Roles Resources

Affiliation Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Västerbotten, Sweden

Tamara B. Harris

Roles Conceptualization, Data curation, Project administration

Affiliation Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Jiang He

Roles Data curation, Funding acquisition

Affiliations Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America, Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America

Sami Heikkinen

Roles Data curation, Formal analysis

Affiliations Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland

Chew-Kiat Heng

Roles Funding acquisition

Affiliations Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Khoo Teck Puat–National University Children's Medical Institute, National University Health System, Singapore

Makoto Hirata

Roles Validation

Affiliation Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan

Barbara V. Howard

Roles Conceptualization, Data curation, Funding acquisition, Project administration

Affiliations MedStar Health Research Institute, Hyattsville, Maryland, United States of America, Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC, United States of America

M. Arfan Ikram

Roles Data curation, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands

InterAct Consortium

Roles Project administration, Validation

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Ulrich John

Roles Funding acquisition, Project administration, Supervision

Affiliations DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany, Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany

Tomohiro Katsuya

Roles Data curation, Investigation, Resources

Affiliations Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan, Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan

Chiea Chuen Khor

Roles Resources

Affiliations Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore, Department of Biochemistry, National University of Singapore, Singapore, Singapore

Tuomas O. Kilpeläinen

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Woon-Puay Koh

Roles Data curation, Funding acquisition, Investigation, Project administration, Writing – review & editing

Affiliations Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore, Duke-NUS Medical School, Singapore, Singapore

José E. Krieger

Roles Funding acquisition, Investigation, Project administration

Affiliation Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil

Stephen B. Kritchevsky

Roles Data curation, Funding acquisition, Resources, Writing – review & editing

Affiliation Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Michiaki Kubo

Roles Validation

Affiliation Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Johanna Kuusisto

Roles Data curation, Investigation, Writing – review & editing

Affiliation Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

Timo A. Lakka

Roles Writing – review & editing

Affiliations Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland

Carl D. Langefeld

Roles Formal analysis, Writing – review & editing

Affiliation Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Claudia Langenberg

Roles Funding acquisition

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Lenore J. Launer

Roles Resources, Writing – review & editing

Affiliation Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Benjamin Lehne

Roles Formal analysis

Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

Cora E. Lewis

Roles Funding acquisition, Investigation, Project administration

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America

Yize Li

Roles Formal analysis

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Shiow Lin

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Jianjun Liu

Roles Resources

Affiliations Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

Jingmin Liu

Roles Formal analysis

Affiliation WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Marie Loh

Roles Formal analysis

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore

Tin Louie

Roles Formal analysis

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Reedik Mägi

Roles Data curation, Formal analysis, Investigation, Supervision

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Colin A. McKenzie

Roles Writing – review & editing

Affiliation The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica

Thomas Meitinger

Roles Writing – review & editing

Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Technische Universität München, Munich, Germany

Andres Metspalu

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Yuri Milaneschi

Roles Data curation, Formal analysis

Affiliation Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands

Lili Milani

Roles Data curation, Investigation, Resources

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Karen L. Mohlke

Roles Data curation, Funding acquisition, Writing – review & editing

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Yukihide Momozawa

Roles Investigation

Affiliation Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Mike A. Nalls

Roles Data curation, Formal analysis, Supervision

Affiliations Data Tecnica International, Glen Echo, Maryland, United States of America, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

Christopher P. Nelson

Roles Data curation, Writing – review & editing

Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

Nona Sotoodehnia

Roles Writing – review & editing

Affiliation Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, United States of America

Jill M. Norris

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliation Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States of America

Jeff R. O'Connell

Roles Methodology, Software

Affiliations Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Nicholette D. Palmer

Roles Project administration, Supervision, Writing – review & editing

Affiliation Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Thomas Perls

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliation Geriatrics Section, Boston University Medical Center, Boston, Massachusetts, United States of America

Nancy L. Pedersen

Roles Funding acquisition, Supervision

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden

Annette Peters

Roles Data curation, Funding acquisition, Resources, Writing – review & editing

Affiliations Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany

Patricia A. Peyser

Roles Supervision, Writing – review & editing

Affiliation Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Neil Poulter

Roles Writing – review & editing

Affiliation School of Public Health, Imperial College London, London, London, United Kingdom

Leslie J. Raffel

Roles Resources

Affiliation Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California, United States of America

Olli T. Raitakari

Roles Funding acquisition, Project administration, Resources

Affiliations Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

Kathryn Roll

Roles Data curation, Project administration

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

Lynda M. Rose

Roles Data curation, Formal analysis, Resources

Affiliation Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Frits R. Rosendaal

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliation Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Jerome I. Rotter

Roles Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

Carsten O. Schmidt

Roles Investigation, Project administration, Writing – review & editing

Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

Pamela J. Schreiner

Roles Resources

Affiliation Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Nicole Schupf

Roles Funding acquisition, Investigation, Writing – review & editing

Affiliation Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America

William R. Scott

Roles Formal analysis

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Peter S. Sever

Roles Project administration, Resources

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom

Yuan Shi

Roles Data curation

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Stephen Sidney

Roles Resources

Affiliation Division of Research, Kaiser Permanente of Northern California, Oakland, California, United States of America

Mario Sims

Roles Formal analysis

Affiliation Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Colleen M. Sitlani

Roles Methodology, Writing – review & editing

Affiliation Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, United States of America

Jennifer A. Smith

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliations Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America, Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America

Harold Snieder

Roles Supervision, Writing – review & editing

Affiliation Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

John M. Starr

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom, Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom

Konstantin Strauch

Roles Data curation, Funding acquisition, Writing – review & editing

Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany

Heather M. Stringham

Roles Formal analysis

Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Nicholas Y. Q. Tan

Roles Project administration

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Hua Tang

Roles Writing – review & editing

Affiliation Department of Genetics, Stanford University, Stanford, California, United States of America

Kent D. Taylor

Roles Investigation

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

Yik Ying Teo

Roles Funding acquisition

Affiliations Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore, Life Sciences Institute, National University of Singapore, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore, Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore

Yih Chung Tham

Roles Project administration

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Stephen T. Turner

Roles Writing – review & editing

Affiliation Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

André G. Uitterlinden

Roles Data curation, Investigation, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Peter Vollenweider

Roles Project administration, Resources

Affiliation Service of Internal Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland

Melanie Waldenberger

Roles Data curation, Supervision, Writing – review & editing

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Lihua Wang

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Ya Xing Wang

Roles Data curation, Resources

Affiliations Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

Wen Bin Wei

Roles Data curation, Resources

Affiliation Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

Christine Williams

Roles Data curation, Formal analysis

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Jie Yao

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America

Caizheng Yu

Roles Formal analysis, Investigation

Affiliation Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Jian-Min Yuan

Roles Funding acquisition, Investigation, Resources, Validation, Writing – review & editing

Affiliations Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Wei Zhao

Roles Data curation, Formal analysis, Software, Writing – review & editing

Affiliation Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Alan B. Zonderman

Roles Data curation, Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Diane M. Becker

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliation Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Michael Boehnke

Roles Funding acquisition, Project administration, Resources

Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Donald W. Bowden

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliation Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

John C. Chambers

Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization

Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, Imperial College Healthcare NHS Trust, London, United Kingdom, MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Ian J. Deary

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom, Psychology, The University of Edinburgh, Edinburgh, United Kingdom

Tõnu Esko

Roles Funding acquisition, Project administration, Resources, Supervision

Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America

Martin Farrall

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom

Paul W. Franks

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden, Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, Massachusetts, United States of America

Barry I. Freedman

Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

Affiliation Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Philippe Froguel

Roles Investigation, Supervision

Affiliations CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France, Department of Genomics of Common Disease, Imperial College London, London, United Kingdom

Paolo Gasparini

Roles Resources

Affiliations Institute for Maternal and Child Health—IRCCS "Burlo Garofolo", Trieste, Italy, Department of Medical Sciences, University of Trieste, Trieste, Italy

Christian Gieger

Roles Data curation, Funding acquisition, Supervision, Writing – review & editing

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

Jost Bruno Jonas

Roles Data curation, Resources

Affiliations Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China, Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, Germany

Yoichiro Kamatani

Roles Validation

Affiliation Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

Norihiro Kato

Roles Data curation, Funding acquisition, Resources, Supervision

Affiliation Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Jaspal S. Kooner

Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization

Affiliations Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom, MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Zoltán Kutalik

Roles Formal analysis

Affiliations Swiss Instititute of Bioinformatics, Lausanne, Switzerland, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland

Markku Laakso

Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

Affiliation Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

Cathy C. Laurie

Roles Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Karin Leander

Roles Data curation, Project administration, Resources, Supervision

Affiliation Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Terho Lehtimäki

Roles Writing – review & editing

Affiliations Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

Lifelines Cohort Study

Roles Investigation, Resources

Affiliation Lifelines Cohort, Groningen, The Netherlands

Patrik K. E. Magnusson

Roles Project administration, Supervision

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden

Albertine J. Oldehinkel

Roles Resources

Affiliation Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Brenda W. J. H. Penninx

Roles Funding acquisition, Project administration, Supervision

Affiliation Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands

Ozren Polasek

Roles Data curation, Investigation, Methodology, Project administration, Supervision

Affiliations Department of Public Health, Department of Medicine, University of Split, Split, Croatia, Psychiatric Hospital "Sveti Ivan", Zagreb, Croatia, Gen-info Ltd, Zagreb, Croatia

David J. Porteous

Roles Data curation

Affiliation Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Rainer Rauramaa

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision

Affiliation Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

Nilesh J. Samani

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

James Scott

Roles Funding acquisition

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom

Xiao-Ou Shu

Roles Data curation, Funding acquisition, Investigation, Resources, Writing – review & editing

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Pim van der Harst

Roles Investigation, Resources, Supervision

Affiliations Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Lynne E. Wagenknecht

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliation Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Nicholas J. Wareham

Roles Funding acquisition

Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

Hugh Watkins

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom

David R. Weir

Roles Investigation, Resources

Affiliation Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America

Ananda R. Wickremasinghe

Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

Affiliation Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

Tangchun Wu

Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Wei Zheng

Roles Data curation, Resources

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Claude Bouchard

Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

Kaare Christensen

Roles Investigation, Writing – review & editing

Affiliation The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Michele K. Evans

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision

Affiliation Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Vilmundur Gudnason

Roles Writing – review & editing

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Bernardo L. Horta

Roles Data curation

Affiliation Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil

Sharon L. R. Kardia

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

Yongmei Liu

Roles Data curation, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

Alexandre C. Pereira

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil

Bruce M. Psaty

Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

Affiliations Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington, United States of America, Kaiser Permanente Washington, Health Research Institute, Seattle, Washington, United States of America

Paul M. Ridker

Roles Funding acquisition, Project administration, Resources

Affiliations Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

Rob M. van Dam

Roles Funding acquisition

Affiliations Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

W. James Gauderman

Roles Writing – review & editing

Affiliation Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, California, United States of America

Xiaofeng Zhu

Roles Funding acquisition, Investigation, Resources, Supervision

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America

Dennis O. Mook-Kanamori

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliations Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

Myriam Fornage

Roles Resources, Supervision, Writing – review & editing

Affiliations Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Charles N. Rotimi

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

L. Adrienne Cupples

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America

Tanika N. Kelly

Roles Formal analysis, Supervision

Affiliation Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America

Ervin R. Fox

Roles Investigation, Supervision, Writing – review & editing

Affiliation Cardiology, Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Caroline Hayward

Roles Data curation

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Cornelia M. van Duijn

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

E Shyong Tai

Roles Funding acquisition, Supervision

Affiliations Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore, Duke-NUS Medical School, Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Tien Yin Wong

Roles Data curation

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Charles Kooperberg

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington, United States of America

Walter Palmas

Roles Investigation, Supervision, Writing – review & editing

Affiliation Medicine, Columbia University Medical Center, New York, New York, United States of America

Kenneth Rice

Roles Conceptualization, Methodology, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Alanna C. Morrison

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Paul Elliott

Roles Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Mark J. Caulfield

Roles Project administration, Resources, Supervision

‡ These authors also contributed equally to this work.

Affiliations Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom

Patricia B. Munroe

Roles Project administration, Resources, Supervision, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliations Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom

Dabeeru C. Rao

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Michael A. Province

Roles Funding acquisition, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing

‡ These authors also contributed equally to this work.

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Daniel Levy

Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

mfeitosa@wustl.edu (MFF); levyD@nih.gov (DL)

‡ These authors also contributed equally to this work.

Affiliations The Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: Bruce M. Psaty (BMP) serves on the DSMB of a clinical trial funded by Zoll Lifecor and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. Barbara V. Howard (BVH) has a contract from National Heart, Lung, and Blood Institute (NHLBI). Brenda W.J.H. Penninx (BWJHP) has received research funding (non-related to the work reported here) from Jansen Research and Boehringer Ingelheim. Mike A. Nalls (MAN) is supported by a consulting contract between Data Tecnica International LLC and the National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA. MAN also consults for Illumina Inc., the Michael J. Fox Foundation, and the University of California Healthcare. MAN also has commercial affiliation with Data Tecnica International, Glen Echo, MD, USA. Mark J. Caulfield (MJC) has commercial affiliation and is Chief Scientist for Genomics England, a UK government company. OHF is supported by grants from Metagenics (on women's health and epigenetics) and from Nestlé (on child health). Peter S. Sever (PSS) is financial supported from several pharmaceutical companies which manufacture either blood pressure lowering or lipid lowering agents, or both, and consultancy fees. Paul W. Franks (PWF) has been a paid consultant in the design of a personalized nutrition trial (PREDICT) as part of a private-public partnership at Kings College London, UK, and has received research support from several pharmaceutical companies as part of European Union Innovative Medicines Initiative (IMI) projects. Terho Lehtimäki (TL) is employed by Fimlab Ltd. Ozren Polašek (OP) is employed by Gen‐info Ltd. There are no patents, products in development, or marked products to declare. All the other authors have declared no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.