http://orcid.org/0000-0002-3357-7872
About the Authors
- Michael J. Thomenius
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: mthomenius@epizyme.com
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Jennifer Totman
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Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Darren Harvey
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Lorna H. Mitchell
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Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Thomas V. Riera
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Kat Cosmopoulos
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Alexandra R. Grassian
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Christine Klaus
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Megan Foley
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Roles Data curation, Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Elizabeth A. Admirand
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Roles Data curation, Methodology, Project administration
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Haris Jahic
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Roles Formal analysis, Investigation, Methodology, Validation
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Christina Majer
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Roles Data curation, Investigation, Methodology, Project administration
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Tim Wigle
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Roles Conceptualization, Investigation, Methodology, Project administration, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Suzanne L. Jacques
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Roles Conceptualization, Investigation, Methodology, Project administration
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Jodi Gureasko
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Roles Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Dorothy Brach
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Roles Data curation, Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Trupti Lingaraj
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Roles Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Kip West
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Roles Conceptualization, Project administration, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Sherri Smith
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Roles Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Nathalie Rioux
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Roles Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Nigel J. Waters
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Roles Investigation, Methodology, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Cuyue Tang
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Roles Formal analysis, Investigation, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Alejandra Raimondi
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Roles Methodology, Project administration, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Michael Munchhof
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Roles Data curation, Formal analysis, Methodology
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- James E. Mills
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Roles Data curation, Formal analysis, Methodology, Software
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Scott Ribich
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Roles Conceptualization, Project administration, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Margaret Porter Scott
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Roles Investigation, Methodology, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Kevin W. Kuntz
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Roles Investigation, Methodology, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- William P. Janzen
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Roles Investigation, Methodology, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Mikel Moyer
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Roles Conceptualization, Project administration, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Jesse J. Smith
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Roles Conceptualization, Investigation, Methodology, Supervision
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Richard Chesworth
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Roles Conceptualization, Project administration, Supervision, Writing – review & editing
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- Robert A. Copeland
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Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
- P. Ann Boriack-Sjodin
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Epizyme, Inc., Cambridge, Massachusetts, United States of America
Competing Interests
This study was funded by Epizyme Inc. All authors are employees of, and/or hold equity in Epizyme, Inc. EPZ028862 and EPZ033294 are products in development and the compounds as well as their use are subject to several U.S. and international patents and patent applications, including but not limited to “Substituted Piperidine Compounds” (PCT/US2015/049235) and “SMYD Inhibitors” (PCT/US2015/049221), both filed on September 9th, 2015. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.