About the Authors
- Anne Walter
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Contributed equally to this work with: Anne Walter, Apirat Chaikuad
Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft
Affiliations Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany, Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Braunschweig, Germany
- Apirat Chaikuad
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Contributed equally to this work with: Anne Walter, Apirat Chaikuad
Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Writing – review & editing
Affiliations Structural Genomics Consortium, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom, Institute for Pharmaceutical Chemistry, Structural Genomics Consortium and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
- Renate Helmer
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Roles Data curation, Investigation, Methodology
Affiliation Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany
- Nadège Loaëc
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Roles Data curation, Formal analysis, Investigation
Affiliation ManRos Therapeutics, Hôtel de Recherche, Centre de Perharidy, Roscoff, France
- Lutz Preu
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Roles Formal analysis, Methodology, Writing – review & editing
Affiliation Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany
- Ingo Ott
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Roles Data curation, Formal analysis, Validation, Writing – review & editing
Affiliations Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany, Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Braunschweig, Germany
- Stefan Knapp
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Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Writing – review & editing
Affiliations Structural Genomics Consortium, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom, Institute for Pharmaceutical Chemistry, Structural Genomics Consortium and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
- Laurent Meijer
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Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: c.kunick@tu-braunschweig.de (CK); meijer@manros-therapeutics.com (LM)
Affiliation ManRos Therapeutics, Hôtel de Recherche, Centre de Perharidy, Roscoff, France
- Conrad Kunick
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Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft
* E-mail: c.kunick@tu-braunschweig.de (CK); meijer@manros-therapeutics.com (LM)
Affiliations Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany, Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Braunschweig, Germany
Competing Interests
The authors have the following interests: NL is employed by and LM is chairman and chief scientific officer of ManRos Therapeutics (Roscoff, France). ManRos Therapeutics develops pharmacological inhibitors of disease-relevant kinases for their use against cystic fibrosis, polycystic kidney disease, Down syndrome and Alzheimer’s disease. Although ManRos is interested in DYRK1A as a potential drug target, it is focused on leucettines and structurally related compounds, and not on the scaffold described in this article (which inhibits the closely related CLKs). In particular, there is no pending patent application or approved patent filed by the authors or the company with regard to the class of compounds or its use described in the submitted article. This study was funded in part by the Structural Genomics Consortium (SGC; http://www.thesgc.org/), a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Janssen, Merck & Co., Novartis Pharma AG, Pfizer and Takeda. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.