About the Authors

Teresa Wright

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

tlwright@alum.mit.edu

Current address: Homology Medicines, Bedford, Massachusetts, United States of America

Affiliation Shire, Lexington, Massachusetts, United States of America

Aiqun Li

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Current address: Sanofi US, Waltham, Massachusetts, United States of America

Affiliation Shire, Lexington, Massachusetts, United States of America

Jason Lotterhand

Roles Investigation, Writing – original draft, Writing – review & editing

Current address: Homology Medicines, Bedford, Massachusetts, United States of America

Affiliation Shire, Lexington, Massachusetts, United States of America

Anne-Renee Graham

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Shire, Lexington, Massachusetts, United States of America

Yan Huang

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Shire, Lexington, Massachusetts, United States of America

Nancy Avila

Roles Investigation, Writing – original draft, Writing – review & editing

Current address: Homology Medicines, Bedford, Massachusetts, United States of America

Affiliation Shire, Lexington, Massachusetts, United States of America

Jing Pan

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Shire, Lexington, Massachusetts, United States of America

Competing Interests

Teresa Wright, Aiqun Li, Jason Lotterhand and Nancy Avila are former employees of Shire, and Teresa Wright is a current stockholder of Shire. Anne Renee Graham, Yan Huang, and Jing Pan are employees and stockholders of Shire. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Shire has an ongoing clinical development program investigating the use of recombinant human arylsulfatase A for the treatment of patients with late-infantile metachromatic leukodystrophy.