About the Authors

Genmin Lu

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Polly Pine

Roles Formal analysis, Validation, Writing – original draft

Current address: Jazz Pharmaceuticals, Palo Alto, CA, United States of America

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Janet M. Leeds

Roles Conceptualization, Formal analysis, Validation, Writing – original draft, Writing – review & editing

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Francis DeGuzman

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Pratikhya Pratikhya

Roles Investigation

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Joyce Lin

Roles Investigation

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

John Malinowski

Roles Investigation, Project administration, Resources

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Stanley J. Hollenbach

Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Current address: Novan Therapeutics, Inc., Durham, NC, United States of America

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

John T. Curnutte

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Pamela B. Conley

Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

pconley@portola.com

Affiliation Portola Pharmaceuticals Inc., South San Francisco, CA, United States of America

Competing Interests

At the time of the study, all authors were employees and stakeholders of Portola Pharmaceuticals. GL holds corporate patents: U.S. Patent No. 8153590: Antidote for factor Xa inhibitor and methods of using the same; GL and PBC hold corporate patents: U.S. Patent No. 8268783: Antidote for factor Xa inhibitor and methods of using the same. This does not alter our adherence to PLOS ONE policies on sharing data and materials.